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PLoS One:腔隙性脑梗塞和大动脉硬化卒中的危险因素比较

2016-05-31 phylis 译 MedSci原创

背景:卒中是中国第二大最常见的死亡原因。虽然缺血性脑卒中各亚型危险因素相似,但是它们有不同的病因。研究者旨在评估腔隙性脑梗塞(LI)和大动脉粥样硬化(LAA)的不同的危险因素情况,并且阐明当前中国急性缺血性脑卒中的特点。方法:在这项横断面研究中,研究者分析2007年到2014年入住北京大学第一医院神经科的1982例急性缺血性卒中患者的临床特点。根据TOAST分类,缺血性脑卒中是进一步分为类为LAA

背景:卒中是中国第二大最常见的死亡原因。虽然缺血性脑卒中各亚型危险因素相似,但是它们有不同的病因。研究者旨在评估腔隙性脑梗塞(LI)和大动脉粥样硬化(LAA)的不同的危险因素情况,并且阐明当前中国急性缺血性脑卒中的特点。

方法:在这项横断面研究中,研究者分析2007年到2014年入住北京大学第一医院神经科的1982例急性缺血性卒中患者的临床特点。根据TOAST分类,缺血性脑卒中是进一步分为类为LAA、LI、心源性脑栓塞(CE)和不明原因脑梗死(UDI)。应用单因素和多因素Logistic分析,1773例LAA和LI患者的人口学特征、危险因素,以及实验室和影像检查结果。

结果:共有1982例缺血性脑卒中患者纳入本研究,1207例诊断为LAA,566例LI,173例为心源性脑栓塞(CE)和36例不明原因脑梗死(UDI)。通过多因素Logistic回归分析危险因素,发现高血压(OR)= 1.832 和脑白质疏松症(WML)(OR= 1.865)与LI更相关。低密度脂蛋白胆固醇(LDL-C)(OR= 0.774)与LAA密切相关。

结论:这项研究发现,高血压和WML与LI密切相关, LDL-C与是LAA密切相关。

原始出处:

Lv P, Jin H, et al. Comparison of Risk Factor between Lacunar Stroke and Large Artery Atherosclerosis Stroke: A Cross-Sectional Study in China. PLoS One. 2016 Mar 2.


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    2016-10-13 ylzr123

    好文,值得推荐。

    0

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    2016-06-02 karmond

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