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JCEM:梅毒感染可导致肾性尿崩症

2014-03-31 佚名 健康报

近日,浙江大学医学院附属邵逸夫医院确诊一例梅毒感染继发肾性尿崩症。该病例资料已发表在美国权威临床内分泌杂志Journal of Clinical Endocrinology & Metabolism上,显示了梅毒临床表现的多样性和继发性肾性尿崩症病因的复杂性。经查阅文献,国际上曾有梅毒感染诱发中枢性尿崩症或肾病综合征、出血性肾炎的报道,但没有梅毒感染导致肾性尿崩症的报道。 56岁出现口

近日,浙江大学医学院附属邵逸夫医院确诊一例梅毒感染继发肾性尿崩症。该病例资料已发表在美国权威临床内分泌杂志Journal of Clinical Endocrinology & Metabolism上,显示了梅毒临床表现的多样性和继发性肾性尿崩症病因的复杂性。经查阅文献,国际上曾有梅毒感染诱发中枢性尿崩症或肾病综合征、出血性肾炎的报道,但没有梅毒感染导致肾性尿崩症的报道。

56岁出现口干、烦渴,每天喝8升~10升水都不顶用。喝得多,尿的也多,老赵每隔1个小时就要解1次小便,到了晚上,频繁上厕所更是严重影响了睡眠。到当地医院做检查,医生怀疑是尿崩症。浙江大学医学院附属邵逸夫医院内分泌科副主任周嘉强给老赵做了禁水加压素试验,结果提示是肾性尿崩症。医生建议他做肾穿刺活检,进一步明确病因。没想到,在术前常规检查中发现,老赵梅毒快速血浆反应素试验结果为1128,梅毒特异性抗体明胶试验和梅毒抗体胶体金试验均为阳性。治疗小组又对肾穿组织进行银染检查,发现组织中有螺旋体样物质,进一步应用抗梅毒螺旋体抗体对病理组织进行免疫组化检查,证实肾脏组织中存在梅毒螺旋体,这才明确诊断为梅毒感染继发肾性尿崩症。

“确诊后,抗梅毒的治疗比较简单,注射青霉素,1个星期打1针,连续3个星期。”周嘉强说,没过多久,老赵多饮多尿症状逐渐好转,生活也恢复正常。

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    2015-08-06 sundong

    所以要预防

    0

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    2014-06-17 achengzhao
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    2014-07-06 smallant2015

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