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J Gastroenterology: 根除幽门螺杆菌后第二个十年的胃癌的发生风险

2019-11-30 不详 MedSci原创

根除幽门螺杆菌可降低患胃癌的风险。在这项研究中,研究人员调查了根除幽门螺杆菌10年后胃癌的发生风险。

背景和目标
根除幽门螺杆菌可降低患癌的风险。在这项研究中,研究人员调查了根除幽门螺杆菌10年后癌的发生风险。

方法
研究人员对2737例幽门螺杆菌感染治愈后接受内镜随访的患者进行了回顾性队列研究。为了比较第二个十年的胃癌风险,研究人员通过将第二个十年的胃癌观察病例数除以第二个十年,计算出标准化发病率(SIR)。使用前十年的年龄发病率比率估算的预期病例样本量。

结果
在长达21.4年(平均7.1年)的随访中,有68例患者(每年0.35%)发展为胃癌。轻度胃黏膜萎缩和中度萎缩的患者中弥漫型胃癌的SIR为无穷大(10.9(95%置信区间4.53-26.1),而SIR并未显着增加。无论基线胃萎缩的程度如何,重度萎缩患者的弥漫型癌症发生率最高。

结论
随访时间越长,基线时轻度至中度胃萎缩的患者发生弥漫型胃癌的风险就越大。治愈幽门螺杆菌后,无论胃萎缩的严重程度如何,都应继续进行内窥镜监测。

原始出处:

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    2020-03-05 风铃830
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    2020-04-26 许安
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    2020-07-19 kcb069
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