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TCT 2018丨LRP研究:NIRS成像对冠脉易损斑块的检测效果较

2018-09-27 国际循环编辑部 国际循环

2018年9月24日,TCT 2018大会公布了LRP研究结果,证明NIRS-IVUS成像检测到的非限流,非干预性,富含脂质斑块的存在与主要不良心血管事件(MACE)发生的相关性来自血管内成像后24个月内易感患者和易损斑块的罪犯病变。

2018年9月24日,TCT 2018大会公布了LRP研究结果,证明NIRS-IVUS成像检测到的非限流,非干预性,富含脂质斑块的存在与主要不良血管事件(MACE)发生的相关性来自血管内成像后24个月内易感患者和易损斑块的罪犯病变。

冠状动脉脂质丰富的斑块可能与之后的心血管事件有关,并且已假设PCI后的结局可通过检测和随后治疗易感患者和富含脂质的脆弱的冠状动脉斑块来改善。血管内近红外光谱(NIRS)具有同时,共同注册的血管内超声(IVUS),可用作双模式导管。

该研究纳入2014年2月~2016年3月,美国和欧洲44个中心进行PCI指导的心导管检查的共计1563例疑似冠状动脉疾病的患者,通过NIRS-IVUS在两支或更多支动脉中进行成像,并且检测2年内患者水平和斑块水平事件。所有随访患者至少有一个maxLCBI 4 mm节段≥250和随机选择50%的患者所有maxLCBI 4 mm节段<250。

在易感患者的分析中,maxLCBI 4 mm每增加100个单位,24个月内出现非罪犯病变MACE事件的风险高于18%。maxLCBI 4 mm≥400的患者MACE率为12.6%,而maxLCBI 4 mm<400患者为6.3%。在易损斑块水平分析中,maxLCBI 4 mm每增加100个单位,24个月内在冠状动脉节段中发生事件的风险高于45%。maxLCBI 4 mm≥400斑块的MACE率为3.7%,而maxLCBI 4 mm˂400的斑块为0.8%。

华盛顿MedStar心血管疾病研究所Ron Waksman教授表示,多血管NIRS可轻松安全地进行,以评估和识别易感患者和易损斑块,NIRS成像可识别并作为具有高风险事件患者的轻度或非梗阻性冠状动脉和非罪犯动脉检查的工具,应考虑用于可行PCI的心导管检查的患者。

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    2018-09-28 一一一多

    新方法,重要的预后结论

    0

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    2018-09-28 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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    2018-09-27 王秀

    学习了,涨知识了!

    0

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