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Addict Biol:重度烟瘾者大脑结构与功能存在异常

2014-07-31 黄艳 新华网

中国科学院武汉物数所的科学家,在一项与武汉大学中南医院合作的科研项目中发现,重度烟瘾者的大脑结构与功能存在异常,且与烟龄以及尼古丁成瘾程度密切相关。据主导这项科研项目的中国科学院武汉物数所研究员雷皓介绍,这项研究利用磁共振成像技术,研究平均年龄在50岁左右、烟龄25年以上、每天吸烟2包以上频率的重度吸烟者的大脑结构与功能。研究结果显示,重度吸烟者胼胝体膝部存在白质微结构异常,其严重程度与烟龄密切相

中国科学院武汉物数所的科学家,在一项与武汉大学中南医院合作的科研项目中发现,重度烟瘾者的大脑结构与功能存在异常,且与烟龄以及尼古丁成瘾程度密切相关。

据主导这项科研项目的中国科学院武汉物数所研究员雷皓介绍,这项研究利用磁共振成像技术,研究平均年龄在50岁左右、烟龄25年以上、每天吸烟2包以上频率的重度吸烟者的大脑结构与功能。研究结果显示,重度吸烟者胼胝体膝部存在白质微结构异常,其严重程度与烟龄密切相关。

通俗而言,就是重度吸烟者的前额左右大脑连接处的神经纤维,其微结构出现异常。而人的前额大脑属于高级功能区,主要管理情绪、判断、选择等功能,如果因微结构异常出现信息传输不畅,则可能影响人对情绪的管理能力以及相关执行力。

研究人员还利用图论的手段分析了重度吸烟者的大脑功能网络,结果也显示出异常。数据显示:相较于不吸烟者,长期重度吸烟者的大脑功能网络全局效率降低,但局部效率增加;全局效率降低部分主要发生在脑默认网络,而局部效率增加主要出现在视觉、注意力相关的脑区域。

雷皓介绍说,与脑结构异常一样,研究所发现的脑功能网络异常也与烟龄以及尼古丁成瘾程度密切相关,即烟龄越长、烟瘾越重以及对尼古丁依靠程度越高,异常出现的频率以及程度就越大。

专家认为,这些研究为深入理解尼古丁成瘾的神经机制以及吸烟对大脑的危害提供了基础数据。目前,研究成果的相关文章已经在线发表在国际物质成瘾权威杂志Addiction Biology 上。这项名为“重度吸烟对大脑结构与功能的影响”的科研项目得到了国家自然基金委和科技部的支持。

原始出处:

Lin F1, Wu G, Zhu L, Lei H.Altered brain functional networks in heavy smokers.Addict Biol. 2014 Jun 24. doi: 10.1111/adb.12155. [Epub ahead of print]

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    2015-01-08 sunylz
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    2014-09-25 jeanqiuqiu
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1917055, encodeId=5149191e055e4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 08 18:23:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858584, encodeId=f523185858465, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Thu Sep 25 19:23:00 CST 2014, time=2014-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805629, encodeId=a2c0180562923, content=<a href='/topic/show?id=89e6e8575ae' target=_blank style='color:#2F92EE;'>#结构与功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78575, encryptionId=89e6e8575ae, topicName=结构与功能)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Feb 07 09:23:00 CST 2015, time=2015-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1766882, encodeId=3ca51e66882be, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Apr 08 09:23:00 CST 2015, time=2015-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424010, encodeId=816314240108d, content=<a href='/topic/show?id=34db439533f' target=_blank style='color:#2F92EE;'>#大脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43953, encryptionId=34db439533f, topicName=大脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d9a3889985, createdName=shanyongle, createdTime=Sat Aug 02 05:23:00 CST 2014, time=2014-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556483, encodeId=8e2215564838d, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Sat Aug 02 05:23:00 CST 2014, time=2014-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10795, encodeId=eb9810e95c3, content=吸烟者越吸越傻?, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=635997983, createdName=xiaoxifeng, createdTime=Fri Aug 01 08:08:00 CST 2014, time=2014-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10791, encodeId=a85210e9167, content=DTI具有这个作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jul 31 21:01:00 CST 2014, time=2014-07-31, status=1, ipAttribution=)]
    2014-08-02 wmr116
  7. [GetPortalCommentsPageByObjectIdResponse(id=1917055, encodeId=5149191e055e4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 08 18:23:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858584, encodeId=f523185858465, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Thu Sep 25 19:23:00 CST 2014, time=2014-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805629, encodeId=a2c0180562923, content=<a href='/topic/show?id=89e6e8575ae' target=_blank style='color:#2F92EE;'>#结构与功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78575, encryptionId=89e6e8575ae, topicName=结构与功能)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Feb 07 09:23:00 CST 2015, time=2015-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1766882, encodeId=3ca51e66882be, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Apr 08 09:23:00 CST 2015, time=2015-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424010, encodeId=816314240108d, content=<a href='/topic/show?id=34db439533f' target=_blank style='color:#2F92EE;'>#大脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43953, encryptionId=34db439533f, topicName=大脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d9a3889985, createdName=shanyongle, createdTime=Sat Aug 02 05:23:00 CST 2014, time=2014-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556483, encodeId=8e2215564838d, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Sat Aug 02 05:23:00 CST 2014, time=2014-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10795, encodeId=eb9810e95c3, content=吸烟者越吸越傻?, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=635997983, createdName=xiaoxifeng, createdTime=Fri Aug 01 08:08:00 CST 2014, time=2014-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10791, encodeId=a85210e9167, content=DTI具有这个作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jul 31 21:01:00 CST 2014, time=2014-07-31, status=1, ipAttribution=)]
    2014-08-01 xiaoxifeng

    吸烟者越吸越傻?

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1917055, encodeId=5149191e055e4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 08 18:23:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858584, encodeId=f523185858465, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Thu Sep 25 19:23:00 CST 2014, time=2014-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805629, encodeId=a2c0180562923, content=<a href='/topic/show?id=89e6e8575ae' target=_blank style='color:#2F92EE;'>#结构与功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78575, encryptionId=89e6e8575ae, topicName=结构与功能)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Feb 07 09:23:00 CST 2015, time=2015-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1766882, encodeId=3ca51e66882be, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Apr 08 09:23:00 CST 2015, time=2015-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424010, encodeId=816314240108d, content=<a href='/topic/show?id=34db439533f' target=_blank style='color:#2F92EE;'>#大脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43953, encryptionId=34db439533f, topicName=大脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d9a3889985, createdName=shanyongle, createdTime=Sat Aug 02 05:23:00 CST 2014, time=2014-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556483, encodeId=8e2215564838d, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Sat Aug 02 05:23:00 CST 2014, time=2014-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10795, encodeId=eb9810e95c3, content=吸烟者越吸越傻?, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=635997983, createdName=xiaoxifeng, createdTime=Fri Aug 01 08:08:00 CST 2014, time=2014-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10791, encodeId=a85210e9167, content=DTI具有这个作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jul 31 21:01:00 CST 2014, time=2014-07-31, status=1, ipAttribution=)]
    2014-07-31 lovetcm

    DTI具有这个作用

    0

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