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J Infect Dis:有的人免疫力更好,这也与基因相关?

2016-01-25 佚名 生物谷

 图片来自:http://www.popsci.com/ 每个人的体内,DNA决定了所有的蛋白质的合成以及修饰,还决定了这些蛋白质的行为。不仅如此,最新的一项研究表明,DNA也强烈地影响人体的免疫系统,使不同的人容易受到细菌感染之后身体的抵御力也有所不同。该研究由来自美国杜克大学为首的研究人员完成,该研究结果发表在本周的《Journal of Infectious Diseases

 图片来自:http://www.popsci.com/

每个人的体内,DNA决定了所有的蛋白质的合成以及修饰,还决定了这些蛋白质的行为。不仅如此,最新的一项研究表明,DNA也强烈地影响人体的免疫系统,使不同的人容易受到细菌感染之后身体的抵御力也有所不同。该研究由来自美国杜克大学为首的研究人员完成,该研究结果发表在本周的《Journal of Infectious Diseases》上。

科学家们发现了一些传染性疾病的免疫为基因所影响的例子。例如,携带囊性纤维化基因突变的患者,往往被发现对于伤寒有抵御力,而伤寒就被认为是一种由细菌引起的疾病。不仅如此,细菌和病毒,反过来,也可以影响人的基因。

在这项研究中,研究人员想了解,不同基因型的人,会不会对于一些比较常见的细菌性感染有着不同的免疫力。研究人员利用大肠杆菌了感染的30名志愿者。大肠杆菌可以在志愿者体内导致腹泻。在接下来的8天里,研究人员观察了志愿者表现出的症状。这其中,六个人完全没有任何症状,另外六个人有轻微的腹泻,其他人都有腹泻症状。随后,研究人员采集了志愿者的血液。研究人员接着检测了血液中的基因表达。而每一个细胞可能具有数千个基因的,只有一小部分是在任何给定的时间被激活,基因的表达谱与外界因素有着很大影响,比如饮食、烟酒等都会影响基因表达。

细菌,似乎也可以影响基因的表达,当研究人员比较参与者们的基因表达情况时,他们发现了与免疫功能有关29基因的表达存在显著差异。似乎这基因在细菌存在时,表达才会变强,使得参与者获得对于细菌的免疫。他们预计,这些变化可能有助于预测哪些病人会对大肠杆菌感染反应强烈。这个研究表明了,在细菌感染时候,基因表达的模式存在着个体差异。有的人对于一些细菌感染更有免疫力,其他人则不然。针对这些免疫相关的基因的深入研究,以及在其他类型的细菌、病毒感染中继续发现免疫相关的基因,对于未来治疗细菌性感染又开辟了新的途径,即可以利用自身的免疫相关基因表达,避免了抗生素类药物的使用。

原始出处:

William E. Yang, Sunil Suchindran,et al, Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans

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    2016-01-27 李继凯

    强大的基因

    0

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    2016-01-27 文医生

    基因的原因吗?

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2012063, encodeId=ea792012063f1, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Apr 12 21:14:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60723, encodeId=993b60e2313, content=强大的基因, beContent=null, objectType=article, channel=null, level=null, likeNumber=205, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 12:46:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60581, encodeId=59236058153, content=基因的原因吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 12:30:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307684, encodeId=c5ab130e6844a, content=<a href='/topic/show?id=85d2289e188' target=_blank style='color:#2F92EE;'>#免疫力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28971, encryptionId=85d2289e188, topicName=免疫力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59604, encodeId=af4e596042b, content=基因很重要,身体靠父母?, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6dc1665697, createdName=xi.xiong, createdTime=Tue Jan 26 16:02:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59578, encodeId=aefd595e84d, content=值得关注了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 15:07:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59546, encodeId=b54959546be, content=万病都和基因有关?, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jan 26 14:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59370, encodeId=5069593e079, content=真的有关吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Tue Jan 26 13:37:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-26 xi.xiong

    基因很重要,身体靠父母?

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2012063, encodeId=ea792012063f1, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Apr 12 21:14:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60723, encodeId=993b60e2313, content=强大的基因, beContent=null, objectType=article, channel=null, level=null, likeNumber=205, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 12:46:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60581, encodeId=59236058153, content=基因的原因吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 12:30:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307684, encodeId=c5ab130e6844a, content=<a href='/topic/show?id=85d2289e188' target=_blank style='color:#2F92EE;'>#免疫力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28971, encryptionId=85d2289e188, topicName=免疫力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59604, encodeId=af4e596042b, content=基因很重要,身体靠父母?, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6dc1665697, createdName=xi.xiong, createdTime=Tue Jan 26 16:02:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59578, encodeId=aefd595e84d, content=值得关注了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 15:07:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59546, encodeId=b54959546be, content=万病都和基因有关?, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jan 26 14:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59370, encodeId=5069593e079, content=真的有关吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Tue Jan 26 13:37:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-26 doctording1

    值得关注了解一下

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2012063, encodeId=ea792012063f1, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Apr 12 21:14:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60723, encodeId=993b60e2313, content=强大的基因, beContent=null, objectType=article, channel=null, level=null, likeNumber=205, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 12:46:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60581, encodeId=59236058153, content=基因的原因吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 12:30:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307684, encodeId=c5ab130e6844a, content=<a href='/topic/show?id=85d2289e188' target=_blank style='color:#2F92EE;'>#免疫力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28971, encryptionId=85d2289e188, topicName=免疫力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59604, encodeId=af4e596042b, content=基因很重要,身体靠父母?, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6dc1665697, createdName=xi.xiong, createdTime=Tue Jan 26 16:02:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59578, encodeId=aefd595e84d, content=值得关注了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 15:07:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59546, encodeId=b54959546be, content=万病都和基因有关?, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jan 26 14:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59370, encodeId=5069593e079, content=真的有关吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Tue Jan 26 13:37:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-26 I come

    万病都和基因有关?

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2012063, encodeId=ea792012063f1, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Apr 12 21:14:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60723, encodeId=993b60e2313, content=强大的基因, beContent=null, objectType=article, channel=null, level=null, likeNumber=205, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 12:46:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60581, encodeId=59236058153, content=基因的原因吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 12:30:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307684, encodeId=c5ab130e6844a, content=<a href='/topic/show?id=85d2289e188' target=_blank style='color:#2F92EE;'>#免疫力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28971, encryptionId=85d2289e188, topicName=免疫力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Wed Jan 27 09:14:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59604, encodeId=af4e596042b, content=基因很重要,身体靠父母?, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6dc1665697, createdName=xi.xiong, createdTime=Tue Jan 26 16:02:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59578, encodeId=aefd595e84d, content=值得关注了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 15:07:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59546, encodeId=b54959546be, content=万病都和基因有关?, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jan 26 14:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59370, encodeId=5069593e079, content=真的有关吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Tue Jan 26 13:37:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-26 文医生

    真的有关吗

    0

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