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Clin Res Cardiol:NT-proBNP可预测无症状性高血压和糖尿病患者的预后

2015-11-15 phylis 译 MedSci原创

背景:无症状性高血压和无临床心衰(HF)症状的糖尿病患者钠尿肽和临床预后之间的关系尚不清楚。在无症状,A / BHF高血压和糖尿病患者中,研究者评估了N端脑钠肽前体(NT-前BNP)的预测价值,及与年龄和性别之间的关系。方法:检测了1012名高血压和/或无HF心衰症状的糖尿病(66.6±7.8岁,48%为男性)无症状患者NT-proBNP。对患者进行前瞻性随访超过49.8±6.7个月,主要随访患者

背景:无症状性高血压和无临床心衰(HF)症状的糖尿病患者的BNP和临床预后之间的关系尚不清楚。在无症状高血压、A / B级心衰的高血压和糖尿病患者中,研究者评估其NT-proBNP的预测价值,及与年龄和性别之间的关系。

方法:检测了1012名无症状性高血压和/或无心衰症状的糖尿病患者(66.6±7.8岁,48%为男性)的NT-proBNP。对患者进行前瞻性随访超过49.8±6.7个月,主要随访患者心源性死亡、因HF住院和非致死性心肌梗死的发生。

结果:与NT-proBNP低于界值点的患者相比,高于界值点(百分位数为80)的患者,风险事件发生增加三倍(HR 3.2 [2.6-8.3])。在多变量分析中,NT-proBNP增加独立的预后信息包括已经建立的风险因素的预测模型。按年龄分层后,增加了NT-proBNP预测第二和第三岁年龄组患者的预后,不能预测第一年龄组预后。NT-proBNP增高与女性风险增加3.6倍和男性风险增加2.9倍相关。NT-proBNP的性别相关的预后模型,进一步提高了预测事件发生的能力。

结论:患者NT-proBNP可增加对无临床症状高血压、A-B期心衰的高血压和糖尿病患者临床预后的预测能力。这种预测价值需要在老年人和女性患者中进一步研究。

原文出处:

Ballo P, Betti I, Barchielli A, et al. Prognostic role of N-terminal pro-brain natriuretic peptide in asymptomatic hypertensive and diabetic patients in primary care: impact of age and gender : Results from the PROBE-HF study. Clin Res Cardiol. 2015, Nov 7.


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    2015-11-17 huiwelcome
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    2015-11-17 sunylz

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