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Neurology:DTI可用于早期诊断卒中后视觉障碍

2016-06-29 phylis 译 MedSci原创

目的:研究者调查扩散张量成像(DTI)显示白质完整性指数是否可用为卒中后视觉系统逆行跨突触变性(RTD)的早期标志物。方法:研究者进行一项前瞻性纵向分析,12例突触后视觉通路的脑卒中患者,12脑卒中患者,和28例健康对照,DTI生物标记指标的健康敏感性。研究者比较组间的差异(1)视神经束的各向异性分数(FA不对称),(2)视力障碍视野的检测,及(3)FA不对称和视野的评估之间的关系。结果:与对照组

目的:研究者调查扩散张量成像(DTI)显示白质完整性指数是否可用为卒中后视觉系统逆行跨突触变性(RTD)的早期标志物。

方法:研究者进行一项前瞻性纵向分析,12例突触后视觉通路的脑卒中患者,12脑卒中患者,和28例健康对照,DTI生物标记指标的健康敏感性。研究者比较组间的差异(1)视神经束的各向异性分数(FA不对称),(2)视力障碍视野的检测,及(3)FA不对称和视野的评估之间的关系。

结果:与对照组相比,视觉通路病变的患者FA-不对称较高。从受伤时间开始,3个月时这些差异是明显的,在12个月没有显著地变化。视觉通路卒中者显示视野检查受损,对照组无视野受损。FA-不对称和3个月内视野检查显著相关性,在12个月仍有相关性。

结论:损伤时间3个月,DTI作为RTD的指标很明显。这是最早的RTD非侵入性检查的证据。
此外,这些检查与视觉障碍检查相关。DTI检查提供一个可重复的,非侵入性的,并且敏感的调查RTD及视觉障碍作用的方法。

原始出处:

Patel KR, Ramsey LE, et al. Early diffusion evidence of retrograde transsynaptic degeneration in the human visual system. Neurology. 2016 Jun 15.


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    2016-11-26 yinhl1978
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    2016-10-11 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

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    2016-10-06 whlxd
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    2016-07-01 zywlvao
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    2016-07-01 微分

    嘎嘎嘎,不错,高端

    0

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