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代谢性心血管危险因素的年龄相关性存在人群差异

2012-04-11 高晓方译 医学论坛网

  多国学者的一项研究表明,主要代谢性心血管病危险因素随年龄增加而升高的情况在不同人群中差异明显,空腹血糖和总胆固醇表现尤为显著。论文于2012年4月4日在线发表于《循环》(Circulation)杂志。   年龄相关性心血管病可能部分由其代谢危险因素倾向于随年龄增加而升高所致。在同一人群中分析年龄相关性多重代谢风险的研究较为匮乏。此项研究利用了来自52个国家的83项全国性或亚全国性健康调

  多国学者的一项研究表明,主要代谢性心血管病危险因素随年龄增加而升高的情况在不同人群中差异明显,空腹血糖和总胆固醇表现尤为显著。论文于2012年4月4日在线发表于《循环》(Circulation)杂志。

  年龄相关性心血管病可能部分由其代谢危险因素倾向于随年龄增加而升高所致。在同一人群中分析年龄相关性多重代谢风险的研究较为匮乏。此项研究利用了来自52个国家的83项全国性或亚全国性健康调查个人记录,并就30~64岁时收缩压和空腹血糖以及30~54岁时总胆固醇的危险因素资料将其适用于线性模型。在老年人群中对非线性相关性亦加以评估。

  结果显示,在30~64岁期间,不同国家男、女性受试者的收缩压每10年升高1.7~11.6 mmHg,空腹血糖每10年升高0.8~20.4 mg/dl。在30~54岁期间,不同调查男、女性受试者的总胆固醇每10年升高0.2~22.4 mg/dl。在大部分国家中以及对所有危险因素而言,女性危险因素水平的升速大于男性,总胆固醇则尤为显著。平均而言,老年时年龄-收缩压相关性表现平坦,总胆固醇和空腹血糖的年龄相关性在老年时出现逆转,导致老年时相关性水平低于中年时。

  链接:

  The Age Associations of Blood Pressure, Cholesterol and Glucose: Analysis of Health Examination Surveys from International Populations



    

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    2012-12-22 sodoo
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