Ann Clin Transl Neurol：老年痴呆，皮肤测试早诊断

2015-02-27 佚名生物谷

根据公布在第67届美国神经病学会的一项研究：科学家发现皮肤测试可能有助更早揭示阿尔茨海默氏症和帕金森氏病。新研究表明，皮肤活检可用于检测这两种疾病中某些异常蛋白水平的升高。   研究报告的作者Ildefonso Rodriguez-Leyva，MD表示：到现在为止，没有脑活检的话，病理证实疾病是不可能的，所以这些疾病经常得不到诊断，直到病情进展。研究假设在胚胎时，皮肤与脑组织一

根据公布在第67届美国神经病学会的一项研究：科学家发现皮肤测试可能有助更早揭示阿尔茨海默氏症和帕金森氏病。新研究表明，皮肤活检可用于检测这两种疾病中某些异常蛋白水平的升高。

研究报告的作者Ildefonso Rodriguez-Leyva，MD表示：到现在为止，没有脑活检的话，病理证实疾病是不可能的，所以这些疾病经常得不到诊断，直到病情进展。研究假设在胚胎时，皮肤与脑组织一样具有相同的来源，它们可能也显示有相同的异常蛋白。

这个新的测试提供了一个潜在的生物标志物，可能让医生更早期识别和诊断这些疾病。在这项研究中，研究人员从20名阿尔茨海默氏症患者，16名帕金森氏病患者和17名其他原因引起的痴呆患者，以及在同一年龄段的12名健康人中获得皮肤活检。他们测试了这些皮肤样本，看看是否能发现特定类型蛋白（即能预示一个人有老年痴呆症或帕金森氏的蛋白）的改变。

相比于健康患者和那些其它原因引起的痴呆症，那些同时有阿尔茨海默氏症和帕金森氏的患者有7倍更高水平的tau蛋白。与健康对照组相比，帕金森氏患者也有α-突触核蛋白蛋白质8倍高的水平。值得注意的是虽然结果是令人兴奋的，但需要更多的研究来证实这些结果。

生物谷授权转载！

原始出处：

Skin test may shed new light on Alzheimer's and Parkinson's diseases

Rodríguez-Leyva I1, Calderón-Garcidueñas AL2, Jiménez-Capdeville ME3, Rentería-Palomo AA1, Hernandez-Rodriguez HG1, Valdés-Rodríguez R4, Fuentes-Ahumada C4, Torres-Álvarez B4, Sepúlveda-Saavedra J5, Soto-Domínguez A6, Santoyo ME3, Rodriguez-Moreno JI1, Castanedo-Cázares JP4.α-Synuclein inclusions in the skin of Parkinson's disease and parkinsonism.Ann Clin Transl Neurol. 2014 Jul;1(7):471-8. doi: 10.1002/acn3.78. Epub 2014 Jul 1.

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2015-10-23 yhj-time

#早诊断#

61 0
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2015-07-04 ms3025846204744509

#Transl#

63 0
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2015-12-14 bsmagic9140

#TRA#

0 0
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2015-04-03 yinhl1978

#Neurol#

57 0
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2015-03-12 lyrichen

赞

118 0
[GetPortalCommentsPageByObjectIdResponse(id=2005037, encodeId=cba4200503e3a, content=<a href='/topic/show?id=1df05950856' target=_blank style='color:#2F92EE;'>#早诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59508, encryptionId=1df05950856, topicName=早诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37d0457, createdName=yhj-time, createdTime=Fri Oct 23 04:17:00 CST 2015, time=2015-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067160, encodeId=c376206e16051, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jul 04 01:17:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656653, encodeId=5378165665333, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Dec 14 16:17:00 CST 2015, time=2015-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999506, encodeId=d6971999506ab, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Apr 03 03:17:00 CST 2015, time=2015-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18153, encodeId=ee01181531a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=lyrichen, createdTime=Thu Mar 12 15:36:00 CST 2015, time=2015-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17214, encodeId=74ad1e2142e, content=不错的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sat Feb 28 11:00:00 CST 2015, time=2015-02-28, status=1, ipAttribution=)]
2015-02-28 xiaoai5777

不错的文章，学习了

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