Personalis, Inc.新发表的数据显示，新型复合生物标志物NEOPS™可用于预测晚期黑色素瘤患者对癌症免疫治疗药物的应答

2021-08-03 国际文传网络

先进转化基因组学和癌症诊断试剂领域的领导者Personalis其研究“通过新抗原负荷和免疫相关耐药机制的联合建模预测黑色素瘤对免疫治疗药物的应答”(1)已发布在美国癌症研究学会出版的《临床癌症研究》上

先进转化基因组学和癌症诊断试剂领域的领导者Personalis, Inc. (Nasdaq: PSNL)今天宣布，其研究“通过新抗原负荷和免疫相关耐药机制的联合建模预测黑色素瘤对免疫治疗药物的应答”⁽¹⁾已发布在美国癌症研究学会出版的《临床癌症研究》(Clinical Cancer Research)期刊中。

该研究详细介绍了Personalis Neoantigen Presentation Score (NEOPS™)的开发。NEOPS是一种用于预测癌症免疫治疗药物应答的新型复合生物标志物。通过来自Personalis NeXT Platform的全方位肿瘤免疫基因组分析，NEOPS同时对新抗原负荷和免疫相关耐药机制进行建模，以更好地预测一组晚期黑色素瘤患者对免疫治疗药物的应答。该研究中，NEOPS相比于经过测试的其他标准单一分析物和在研生物标志物（包括肿瘤突变负担）更能预测治疗应答。这种复合生物标志物的性能在一组接受免疫检查点阻断治疗药物的晚期黑色素瘤患者队列中进行了最初测试，随后在一组接受类似治疗的晚期黑色素瘤患者的独立数据集中得到了验证。

Personalis首席医学官Richard Chen, MD表示：“鉴于对免疫治疗药物的不同应答和治疗相关的潜在毒性，需要改进生物标志物方法来更好地预测哪些患者会对治疗药物有应答。我们的研究结果提示，像NEOPS这样的综合性、多组学生物标志物比那些较简单的单一分析物方法更能预测应答，尤其是在控制应答的基础生物学机制非常复杂的新型抗癌药中。我们认为NEOPS和其他复合生物标志物将成为实现精准肿瘤学的重要且更敏锐的工具。”

NEOPS采用Personalis自2015年以来一直在开发的技术来更好地预测新抗原并识别相关的逃逸机制，例如HLA LOH。我们的ImmunoID NeXT和临床NeXT Dx检测使包括NEOPS在内的这种先进功能可供药企研究人员和临床医生用于临床试验和研究用途，并计划对其他类型肿瘤进行进一步的临床研究。

前瞻性陈述

本新闻稿中所有非历史性陈述均属于美国证券法所定义的“前瞻性陈述”，包括与下列有关的陈述：NEOPS或Personalis NeXT Platform、Personalis的商机、领导地位、规划、愿景或增长或其他未来事件。此类前瞻性陈述涉及风险和不确定性，包括新冠疫情相关的风险和不确定性，有可能导致实际结果与此类陈述所表达或暗示的任何预期结果或预期存在重大差异。可在Personalis向美国证券交易委员会提交的文件中找到可能对实际结果产生重大影响的因素，包括Personalis的最新Form 8-K、10-K和10-Q报告，并包括“风险因素”标题下列出的内容。Personalis不承担更新此类前瞻性陈述的任何义务。

⁽¹⁾ Clin Cancer Res August 1 2021 (27) (15) 4265-4276; DOI: 10.1158/1078-0432.CCR-20-4314

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2021-12-29 hukaixun

#标志物#

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2022-03-19 周虎

#治疗药物#

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2022-01-26 anminleiryan

#ERS#

62 0
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content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=)]
2022-06-22 1249842em09(暂无昵称)

#免疫治疗药物#

93 0
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channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561058, encodeId=0f79156105838, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565087, encodeId=84bf156508e9d, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=)]
2022-05-11 feather89

#PE#

60 0
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objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Sun Apr 03 23:43:28 CST 2022, time=2022-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1010967, encodeId=f4b5101096eee, content=学习了~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3345583185, createdName=dream11, createdTime=Tue Aug 24 14:44:56 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559078, encodeId=b1db15590e8bf, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561058, encodeId=0f79156105838, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565087, encodeId=84bf156508e9d, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=)]
2022-04-03 sunylz

#色素#

56 0
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content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=)]
2021-08-24 dream11

学习了~~

95 0
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channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561058, encodeId=0f79156105838, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565087, encodeId=84bf156508e9d, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=)]
2021-08-05 cqlidoudou

#黑色素#

72 0
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encryptionId=fc9a290e1cb, topicName=免疫治疗药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Wed Jun 22 00:43:28 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729067, encodeId=2a0a1e29067cb, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed May 11 11:43:28 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680745, encodeId=910f1680e45e3, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Sun Apr 03 23:43:28 CST 2022, time=2022-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1010967, encodeId=f4b5101096eee, content=学习了~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3345583185, createdName=dream11, createdTime=Tue Aug 24 14:44:56 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559078, encodeId=b1db15590e8bf, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, 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content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=)]
2021-08-05 zhu_jun9842

#生物标志#

51 0
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channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561058, encodeId=0f79156105838, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565087, encodeId=84bf156508e9d, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Thu Aug 05 05:43:28 CST 2021, time=2021-08-05, status=1, ipAttribution=)]
2021-08-05 cqlidoudou

#黑色素#

55 0

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Personalis, Inc.新发表的数据显示，新型复合生物标志物NEOPS™可用于预测晚期黑色素瘤患者对癌症免疫治疗药物的应答

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