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ATS:袖状肺叶切除术治疗中央型非小细胞肺癌疗效令人满意

2013-09-03 佚名 丁香园

对于非小细胞肺癌(NSCLC)累及隆突患者而言,袖状肺叶切除术是否可以作为一个治疗策略,手术适应症、手术风险和术后生存率能否令人满意尚未明确。针对这种情况,来自德国海德堡大学胸外科学系的Florian Eichhorn教授等人进行了一项研究,研究结果发表在2013年5月11日的《胸外科年鉴》(Ann Thorac Surg)杂志上。研究发现,中央型NSCLC侵及隆突或近端主

对于非小细胞肺癌(NSCLC)累及隆突患者而言,袖状肺叶切除术是否可以作为一个治疗策略,手术适应症、手术风险和术后生存率能否令人满意尚未明确。针对这种情况,来自德国海德堡大学胸外科学系的Florian Eichhorn教授等人进行了一项研究,研究结果发表在2013年5月11日的《胸外科年鉴》(Ann Thorac Surg)杂志上。研究发现,中央型NSCLC侵及隆突或近端主支气管的患者在特定情况下选择袖状肺叶切除术,其手术风险合理性和术后生存率令人满意。【原文下载

该研究对2000年9月至2011年11月期间连续进行的64例袖状肺叶切除术患者进行了回顾性分析,其中根治性切除组(n=50,78%),姑息性治疗组(n=14,22%)。所有患者均为经病理证实的中央型非小细胞肺癌。研究对这部分患者的适应症、并发症和影响其长期生存的因素进行了统计学分析。

研究发现,入组患者中41%病理为N2,完全切除率达83%。41%的患者出现并发症,其中8%为严重的吻合口并发症,三十天内死亡率为3%(n = 2)。病理淋巴结状态对患者的5年生存率有显著影响,N0,N1,N2组5年生存率分别为70%,35%,9%。N2及有化疗或放疗禁忌症的患者姑息性手术后平均存活时间为13个月。

该研究结果表明,中央型NSCLC侵及隆突或近端主支气管的患者在特定的情况下选择袖状肺叶切除术,其手术风险合理性和生存率令人满意。姑息性袖状肺叶切除术可以作为没有替代治疗时的一种选择。

原文下载

Eichhorn F, Storz K, Hoffmann H, Muley T, Dienemann H.Sleeve pneumonectomy for central non-small cell lung cancer: indications, complications, and survival.Ann Thorac Surg. 2013 Jul;96(1):253-8.


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