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Diabetologia:运动干预2型糖尿病的代谢组学研究取得新进展

2015-07-30 佚名 大连化学物理研究所

近日,中国科学院大连化学物理研究所生物技术研究部高分辨分离分析和代谢组学研究组(1808组)与丹麦哥本哈根大学临床和生物化学系及德国图宾根大学医学院合作,应用代谢组和转录组研究了糖尿病患者对运动的应答,相关研究结果在《糖尿病学》(Diabetologia)杂志作为“up front”文章发表。一直以来,人们认可运动对人类健康的好处,尤其是对2型糖尿病预防和治疗的作用。然而,2型糖尿病对运动过程中的

近日,中国科学院大连化学物理研究所生物技术研究部高分辨分离分析和代谢组学研究组(1808组)与丹麦哥本哈根大学临床和生物化学系及德国图宾根大学医学院合作,应用代谢组和转录组研究了糖尿病患者对运动的应答,相关研究结果在《糖尿病学》(Diabetologia)杂志作为“up front”文章发表。

一直以来,人们认可运动对人类健康的好处,尤其是对2型糖尿病预防和治疗的作用。然而,2型糖尿病对运动过程中的燃料供应和氧化的调节及对基因表达的影响尚不明确。在本次的国际合作研究中,研究人员研究了2型糖尿病患者在50%最大摄氧量条件下运动60分钟对代谢组和转录组的影响。结果表明,在运动过程中,2型糖尿病患者葡萄糖和脂肪酸的代谢与正常人雷同,但对骨骼肌中葡萄糖和氨基酸的代谢调节比正常人更为显著。相比正常人,糖尿病患者可以从中等强度的运动中获得更大的好处。研究结果提供了改善2型糖尿病患者血糖和氨基酸代谢新机制的证据。

大连化物所1808组与德国图宾根大学医学院近年来一直合作进行糖尿病相关的研究,在重要代谢物的功能(J Clin Endocrinol Metab. 2013 Jun;98(6):E1137-42.,Diabetes Care. 2013 Aug;36(8):2331-8.)、棕色脂肪的组成(Biochim Biophys Acta. 2014 Oct;1842(10):1563-70)、生活方式对健康的影响等方面取得了较好的研究结果。

该研究得到了中德科学中心项目的支持。



运动干预2型糖尿病的代谢组学研究取得新进展

原始出处:

Jakob S. Hansen, Xinjie Zhao, Martin Irmler, Xinyu Liu, Miriam Hoene, Mika Scheler, Yanjie Li, Johannes Beckers, Martin Hrabĕ de Angelis, Hans-Ulrich Häring, Bente K. Pedersen, Rainer Lehmann, Guowang Xu, Peter Plomgaard, Cora Weigert.Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.Diabetologia.June 12, 2015.

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    2017-05-31 laoli

    学习了,谢谢分享!

    0

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    2016-02-11 xuyu
  5. [GetPortalCommentsPageByObjectIdResponse(id=204888, encodeId=554e20488812, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Wed May 31 19:34:56 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637134, encodeId=5b86163e13420, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Sep 25 17:50:00 CST 2015, time=2015-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759572, encodeId=b8d31e59572d8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Feb 27 01:50:00 CST 2016, time=2016-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804779, encodeId=564c1804e7942, content=<a href='/topic/show?id=c4bee764836' target=_blank style='color:#2F92EE;'>#组学研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77648, encryptionId=c4bee764836, topicName=组学研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Thu Feb 11 20:50:00 CST 2016, time=2016-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35064, encodeId=970835064d0, content=期待有更多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 23:02:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35057, encodeId=bafb3505ee3, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:56:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34066, encodeId=73383406658, content=这么少, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78351636049, createdName=shuaijing1986, createdTime=Sun Aug 02 17:08:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480267, encodeId=d63e148026e16, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Sat Aug 01 07:50:00 CST 2015, time=2015-08-01, status=1, ipAttribution=)]
    2015-08-06 hlycom3356

    期待有更多研究

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=204888, encodeId=554e20488812, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Wed May 31 19:34:56 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637134, encodeId=5b86163e13420, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Sep 25 17:50:00 CST 2015, time=2015-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759572, encodeId=b8d31e59572d8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Feb 27 01:50:00 CST 2016, time=2016-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804779, encodeId=564c1804e7942, content=<a href='/topic/show?id=c4bee764836' target=_blank style='color:#2F92EE;'>#组学研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77648, encryptionId=c4bee764836, topicName=组学研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Thu Feb 11 20:50:00 CST 2016, time=2016-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35064, encodeId=970835064d0, content=期待有更多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 23:02:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35057, encodeId=bafb3505ee3, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:56:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34066, encodeId=73383406658, content=这么少, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78351636049, createdName=shuaijing1986, createdTime=Sun Aug 02 17:08:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480267, encodeId=d63e148026e16, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Sat Aug 01 07:50:00 CST 2015, time=2015-08-01, status=1, ipAttribution=)]
    2015-08-06 hlycom3356

    对目前研究提供了极大帮助

    0

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    2015-08-02 shuaijing1986

    这么少

    0

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该项随机对照临床试验中旨在评估在65-79岁女性绝经后激素治疗(HT),2型糖尿病与脑容量的关系。在这项随机临床试验中患者分别接受平均5.6年的HT或安慰剂治疗。当试验进行到2.4年后,共1402名患者接受了头部磁共振(MRI)检查,有699名患者在4.7年后再次评估。使用线性模型对糖尿病、HT治疗以及大脑体积治疗情况进行评估。结果显示,患有糖尿病的女性组中,在随访期间,HT治疗组中总体大脑体积平

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