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年轻血液隐藏着“青春之泉”的关键?

2016-11-19 佚名 中国生物技术网

延长寿命的倡导者们离“生物青春之泉”更近了一步,一种治疗方法能够使用健康年轻人的血液逆转衰老的影响。在一系列新研究中,研究人员发现,将18岁的年轻人的血浆注射到年老小鼠体内,小鼠的身体和大脑都会变得年轻,认知能力提升,使得它们可以像年轻小鼠一样嬉戏打闹。根据Alkahest公司的说法,血浆也许掌控着年轻的秘密,一种类似的技术也许可以在未来某一天用于人类。这项发现公布于神经科学协会的年度会议上。Al

延长寿命的倡导者们离“生物青春之泉”更近了一步,一种治疗方法能够使用健康年轻人的血液逆转衰老的影响。

在一系列新研究中,研究人员发现,将18岁的年轻人的血浆注射到年老小鼠体内,小鼠的身体和大脑都会变得年轻,认知能力提升,使得它们可以像年轻小鼠一样嬉戏打闹。

根据Alkahest公司的说法,血浆也许掌控着年轻的秘密,一种类似的技术也许可以在未来某一天用于人类。这项发现公布于神经科学协会的年度会议上。

Alkahest公司的使命是“通过抵消衰老过程的变革性治疗充实人类的健康与活力”。该公司将18岁年轻人的血液注射到12个月大的小鼠体内,每周2次,持续3周。

12个月时,小鼠就进入了相当于人类50岁的年纪,移动变得更加缓慢,记忆力更差。

但在三个星期后,研究人员发现小鼠在很多测试中表现有所提升。在注射血液之后,这些年老的小鼠记住迷宫的路能力更强。测试结果与年轻的3个月大的小鼠和未接受血液注射的年老小鼠对比。研究人员还检测了接受这种疗法小鼠的大脑,发现它们的海马体生成了新细胞。这个过程被称为神经发生(neurogenesis),该过程与记忆和学习有关。结果表明,神经发生的过程能够通过注射年轻人的血液得到加强。

Alkahest公司的Sakura Minami称,年轻血液具有如此能力的一些因素已经被确认,但是该团队并未透露。

研究人员说,这项发现在未来可以帮助他们开发出抗衰老治疗的方法,甚至可以帮助阿尔茨海默症患者。目前,人类试验对此假设进行测试。

近几年来,奇怪的实践引起了很多热衷寿命延长的人的注意,包括亿万富翁科技投资人Peter Thiel。

早期的研究发现,输入年轻捐献者的血浆能够在身体中产生逆转衰老的作用,最近已经开始对人类进行临床试验。

人类试验最近由Ambrosia公司启动,受测者需要付8000美元才能参与。

这项研究名为“年轻捐献者的血浆输入和与年龄相关的生物标记”,35岁及以上的健康人被输入小于25岁的年轻的人血浆。

Thiel资本的首席医学官Jason Camm已经联系了该公司,他对这项工作表达了兴趣。

在去年的一次访问中,Peter Thiel解释了他对寿命延长医学的兴趣。

从关于热量限制、人类生长激素和糖尿病药物二甲双胍的讨论开始,这位投资者并不相信科学家们找到了包治百病的技术。

但是,他开始关注一些“陌生的未被开发的”领域。

Thiel说:“我开始关注异种共生(parabiosis),我认为这非常有趣。这项研究中,年轻的血液被注入老年的小鼠,并观察到了返老还童的效果。”



Peter Thiel

Thiel继续解释说,这个过程作为个人健康治疗方法非常有趣,并说它不需要获得FDA的批准。然而,这位投资人说他并没有开始推进异种共生。

科学家们于上世纪50年代首次对异种共生进行实验,近年来,它又开始获得人们的注意。

在人类和动物的器官系统中,这个过程被发现可以逆转衰老的症状,尽管科学家仍不清楚何种机制在起作用。

Ambrosia的建立者Jesse Karmazin说,一个年轻有机体的血液富含能够改善细胞功能的蛋白质,并促进受体中的这些蛋白质的生成。而且,研究人员称这种作用几乎是永久的。

原始出处

Aging mice given blood plasma from young humans regain youthful attributes

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1756773, encodeId=46251e5677374, content=<a href='/topic/show?id=930248998da' target=_blank style='color:#2F92EE;'>#年轻血液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48998, encryptionId=930248998da, topicName=年轻血液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3bea37226670, createdName=751943081_32627961, createdTime=Tue Aug 15 09:41:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167307, encodeId=51f316e307b9, content=学习了,好东东, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160824/IMG57BDA6843F0F38922.jpg, createdBy=8fdd1925645, createdName=1e0b9de5m54(暂无匿称), createdTime=Sun Jan 01 21:10:30 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157313, encodeId=538915e31355, content=真的假的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Nov 21 17:36:16 CST 2016, time=2016-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157101, encodeId=50e315e101c8, content=返老还童!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Nov 20 17:04:11 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157095, encodeId=89fe15e0950d, content=这也为吸血鬼吸血找到依据?年轻血液更充满活力, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCYbPBa7AiaIy1pMpp7CF9lHORw4icR9GOrMO6RVNCb1qSUSY9TFBzW5zlrpDia0HKafiarjvcweMaVdg/0, createdBy=f1d61928636, createdName=simayunhe, createdTime=Sun Nov 20 15:49:43 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157078, encodeId=64ff15e07814, content=那免疫方面的后果怎么办?, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dd71722896, createdName=studylzc, createdTime=Sun Nov 20 14:21:33 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157015, encodeId=334a15e01571, content=嗯很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Nov 20 09:08:41 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156935, encodeId=951815693541, content=这篇文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160905/IMG57CD39B82D12E7926.jpg, createdBy=ac2c1946830, createdName=青龙偃月, createdTime=Sat Nov 19 23:26:29 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2017-01-01 1e0b9de5m54(暂无匿称)

    学习了,好东东

    0

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    2016-11-21 wxl882001

    真的假的

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1756773, encodeId=46251e5677374, content=<a href='/topic/show?id=930248998da' target=_blank style='color:#2F92EE;'>#年轻血液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48998, encryptionId=930248998da, topicName=年轻血液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3bea37226670, createdName=751943081_32627961, createdTime=Tue Aug 15 09:41:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167307, encodeId=51f316e307b9, content=学习了,好东东, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160824/IMG57BDA6843F0F38922.jpg, createdBy=8fdd1925645, createdName=1e0b9de5m54(暂无匿称), createdTime=Sun Jan 01 21:10:30 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157313, encodeId=538915e31355, content=真的假的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Nov 21 17:36:16 CST 2016, time=2016-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157101, encodeId=50e315e101c8, content=返老还童!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Nov 20 17:04:11 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157095, encodeId=89fe15e0950d, content=这也为吸血鬼吸血找到依据?年轻血液更充满活力, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCYbPBa7AiaIy1pMpp7CF9lHORw4icR9GOrMO6RVNCb1qSUSY9TFBzW5zlrpDia0HKafiarjvcweMaVdg/0, createdBy=f1d61928636, createdName=simayunhe, createdTime=Sun Nov 20 15:49:43 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157078, encodeId=64ff15e07814, content=那免疫方面的后果怎么办?, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dd71722896, createdName=studylzc, createdTime=Sun Nov 20 14:21:33 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157015, encodeId=334a15e01571, content=嗯很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Nov 20 09:08:41 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156935, encodeId=951815693541, content=这篇文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160905/IMG57CD39B82D12E7926.jpg, createdBy=ac2c1946830, createdName=青龙偃月, createdTime=Sat Nov 19 23:26:29 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2016-11-20 半夏微凉

    返老还童!

    0

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    2016-11-20 simayunhe

    这也为吸血鬼吸血找到依据?年轻血液更充满活力

    0

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    2016-11-20 studylzc

    那免疫方面的后果怎么办?

    0

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    2016-11-20 李东泽

    嗯很好,不错,以后会多学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1756773, encodeId=46251e5677374, content=<a href='/topic/show?id=930248998da' target=_blank style='color:#2F92EE;'>#年轻血液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48998, encryptionId=930248998da, topicName=年轻血液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3bea37226670, createdName=751943081_32627961, createdTime=Tue Aug 15 09:41:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167307, encodeId=51f316e307b9, content=学习了,好东东, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160824/IMG57BDA6843F0F38922.jpg, createdBy=8fdd1925645, createdName=1e0b9de5m54(暂无匿称), createdTime=Sun Jan 01 21:10:30 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157313, encodeId=538915e31355, content=真的假的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Nov 21 17:36:16 CST 2016, time=2016-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157101, encodeId=50e315e101c8, content=返老还童!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Nov 20 17:04:11 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157095, encodeId=89fe15e0950d, content=这也为吸血鬼吸血找到依据?年轻血液更充满活力, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCYbPBa7AiaIy1pMpp7CF9lHORw4icR9GOrMO6RVNCb1qSUSY9TFBzW5zlrpDia0HKafiarjvcweMaVdg/0, createdBy=f1d61928636, createdName=simayunhe, createdTime=Sun Nov 20 15:49:43 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157078, encodeId=64ff15e07814, content=那免疫方面的后果怎么办?, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dd71722896, createdName=studylzc, createdTime=Sun Nov 20 14:21:33 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157015, encodeId=334a15e01571, content=嗯很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Nov 20 09:08:41 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156935, encodeId=951815693541, content=这篇文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160905/IMG57CD39B82D12E7926.jpg, createdBy=ac2c1946830, createdName=青龙偃月, createdTime=Sat Nov 19 23:26:29 CST 2016, time=2016-11-19, status=1, ipAttribution=)]
    2016-11-19 青龙偃月

    这篇文章不错

    0

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