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Ann Pharmacother:加巴喷丁治疗呃逆耐受性良好

2013-07-26 MedSci MedSci原创

为了评估加巴喷丁治疗顽固性或持续性呃逆的疗效,来自美国俄克拉荷马州立大学药学院的研究者对MEDLINE(1966年~2013年3月)、Web of Science(1945年~2013年3月)和国际药学文摘(1970年~2013年3月)等数据库进行了相关检索,该数据检索结果于2013年6月刊发在The Annals of pharmacotherapy杂志上。由于持续性或顽固性呃逆的发病率较低,鲜

为了评估加巴喷丁治疗顽固性或持续性呃逆的疗效,来自美国俄克拉荷马州立大学药学院的研究者对MEDLINE(1966年~2013年3月)、Web of Science(1945年~2013年3月)和国际药学文摘(1970年~2013年3月)等数据库进行了相关检索,该数据检索结果于2013年6月刊发在The Annals of pharmacotherapy杂志上。
由于持续性或顽固性呃逆的发病率较低,鲜有药物疗效研究的临床对照试验。因此,大多数数据只是来自病例报告或病例系列。

研究者评估了涉及加巴喷丁治疗持续性或顽固性呃逆的17例病例报告和2个病例系列。所有的病例中加巴喷丁治疗的结果都呈阳性,短期的证据表明了疗效,但在某些病例中,结果常被联合治疗与合并症干扰混淆。病例报告表明,加巴喷丁作为二线药物,可能对卒中康复或姑息治疗中对氯丙嗪有不良反应的患者有用。加巴喷丁耐受性良好,副作用较轻。

最后研究者总结道,加巴喷丁治疗呃逆的耐受性良好,可作为某些特定患者的二线治疗药物。

原始出处:

Thompson DF, Brooks KG.Gabapentin therapy of hiccups. Ann Pharmacother. 2013 Jun;47(6):897-903.

Page RL 2nd, Luna M, Brieke A, Lindenfeld J.Low-dose gabapentin for intractable hiccups in a heart transplant recipient. Prog Transplant. 2011 Dec;21(4):340-3

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    2013-10-13 yb6560
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    2013-08-12 jj000001
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