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Cell Immunity: 25-羟基胆固醇,对抗寨卡病毒的新方法

2017-03-20 Leo.C MedSci原创

研究者们发现25-羟基胆固醇能够阻止寨卡病毒进入人的脑皮质细胞从而保护神经细胞和降低小头症的发生率。

寨卡(Zika)病毒,是近期成为危害全球公共卫生的重要威胁。寨卡病毒可以快速的通过蚊虫叮咬和性生活传播,病毒携带者通过国际旅行也为控制病毒感染带来很大的难度。并且寨卡病毒还能感染孕妇从而导致婴儿先天性的疾病。在2015年巴西所发现的寨卡病毒爆发伴随着新生儿小头症(microcephaly),古雷-巴里综合症(Guillain-Barré syndrome,一种先天性肌肉萎缩,以及免疫系统和神经系统疾病), 和脑膜炎。寨卡病毒能够感染神经祖细胞(neural progenitor cells),从而造成细胞死亡或者生长抑制,最终导致小头症。现在对于寨卡病毒的防治,市场上没有有效的抗病毒药物或者疫苗。

在最近上线的Cell Immunity杂志上,Chunfeng Li及其同事报道了一种25-羟基胆固醇(25-Hydroxycholesterol)能够抑制寨卡病毒感染细胞,从而减少小头症的发生。 

抑制寨卡病毒只能感染干扰素IFN缺陷的老鼠模型,暗示着干扰素对于抑制寨卡病毒有很大的作用。催化产生25-羟基胆固醇的酶,胆固醇-25羟基化酶(Cholesterol-25-hydroxylase)是感染干扰素IFN信号激活的下游产物。25-羟基胆固醇基因缺陷的老鼠再感染寨卡病毒后,体内有更高的病毒量,而接受人工合成的25-羟基胆固醇能够保护实验鼠和恒河猴对于寨卡病毒的感染。研究者们发现25-羟基胆固醇能够阻止寨卡病毒进入人的脑皮质细胞从而保护神经细胞和降低小头症的发生率。

这项研究为应对寨卡病毒的感染提供了新的治疗方法,尤其是在预防由寨卡病毒所引起小头症的发生。

原始出处:
Chunfeng Li, Yong-Qiang Deng, Feng Ma, et al. 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. Cell Immunity Available online 14 March 2017 http://dx.doi.org/10.1016/j.immuni.2017.02.012 

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    2017-10-17 维他命
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    2017-05-01 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2017-03-20 knowheart

    寨卡病毒可以快速的通过蚊虫叮咬和性生活传播,病毒携带者通过国际旅行也为控制病毒感染带来很大的难度。

    0

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