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PLOS ONE:我国糖尿病肺结核患者的维生素D状况及相关因素分析

2018-11-03 海北 MedSci原创

维生素D可能是结核病(TB)和糖尿病(DM)之间关联的中介。一项大规模的多中心研究证实,与没有DM的TB患者相比,同时患有DM和TB患者的血清维生素D水平显着降低,并且报告DM是维生素D缺乏的强烈独立危险因素。

维生素D可能是结核病(TB)和糖尿病(DM)之间关联的中介。一项大规模的多中心研究证实,与没有DM的TB患者相比,同时患有DM和TB患者的血清维生素D水平显着降低,并且报告DM是维生素D缺乏的强烈独立危险因素。

最近,我国研究人员进行了一项研究,旨在确定生活在不同经济区的TB和DM患者:i)其基线特征,ii)维生素D状态,iii)某些基线特征是否与维生素D缺乏有关。

在连续参加7个诊所或医院的DM-TB患者中,研究人员使用COBASE 601 Roche分析仪,通过化学发光免疫测定法测量了25羟基胆钙化醇水平,并使用卡方检验和多变量逻辑回归进行数据分析。

该研究共包括178名DM-TB患者,其中50名来自经济发达地区,103名来自富裕地区,25名来自贫困地区。发达,富裕和贫困地区的维生素D中位数分别为11.5ng / ml,12.2ng / ml和11.5ng / ml。在所有患者中,149例患者(84%)维生素D缺乏,其中91例(51%)维生素D缺乏(10-19.9纳克/毫升),58例(33%)严重缺乏(<10纳克/毫升)。贫困地区维生素D缺乏的比例明显较高。在具有更长DM病史的患者(P = 0.038)和HbA1c≥10%(P = 0.003)的患者中,维生素D缺乏(25-(OH)D3 <20 ng / ml)的调整后几率显着更高。

因此,该研究表明,中国80%以上的糖尿病结核病患者缺乏维生素D,危险因素为在贫困地区居住,糖尿病病程长,DM不受控制。结核病项目经理和临床医生需要更加关注患者的维生素D状况。


原始出处:

Zhao X et al. Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China. PLOS ONE, 2018; DOI: 10.1371/journal.pone.0206372. eCollection 2018.


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    2018-11-21 shunshun_9

    收益匪浅

    0

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  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Nov 04 08:04:22 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351459, encodeId=1ba435145920, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Nov 04 08:04:18 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351458, encodeId=21af351458c4, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Nov 04 08:04:13 CST 2018, time=2018-11-04, status=1, ipAttribution=)]
    2018-11-04 不一样的美男

    哈哈

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Nov 04 08:04:13 CST 2018, time=2018-11-04, status=1, ipAttribution=)]
    2018-11-04 Y—xianghai

    学习了长知识

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Nov 04 08:04:13 CST 2018, time=2018-11-04, status=1, ipAttribution=)]
    2018-11-04 Y—xianghai

    学习了长知识

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Nov 04 08:04:13 CST 2018, time=2018-11-04, status=1, ipAttribution=)]
    2018-11-04 Y—xianghai

    学习了长知识

    0

  9. 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    2018-11-04 Y—xianghai

    学习了长知识

    0

  10. 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    2018-11-04 Y—xianghai

    学习了长知识

    0

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深圳市人力资源和社会保障局近日发布《关于肺结核门诊专科治疗享受门诊大病待遇的通知》,自2018年11月1日起,深圳市医疗保险参保人确诊为肺结核或耐多药肺结核的,可到指定的医疗保险定点医疗机构申请门诊大病认定后,其进行相应门诊专科治疗时可享受门诊大病待遇。根据通知,符合条件的参保人申请门诊大病认定的,应向深圳市社会保险基金管理局委托的门诊大病诊断医院相应专科现场提出申请并提交资料,专科医生通过现场

咳血、贫血、肺浸润有点像肺结核 实际是…

特发性肺含铁血黄素沉着症(idiopathic pulmonary hemosiderosis,IPH)是一种罕见的弥漫性肺泡内出血性疾病(diffuse alveolar hemorrhage disease,DAH),病因未明。本病于1865年由Virchow首先描述,IPH多发生于10岁以下儿童,尤以1~2岁居多,成人病例较少见。

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