JCEM：饮食维生素D摄入对骨质疏松性骨折的影响较小

2013-12-18 佚名丁香园

膳食中维生素D在预防骨质疏松性骨折中的重要性尚不确定。为了探讨饮食中维生素D摄入与骨折和骨质疏松风险之间的关系，来自瑞典乌普萨拉大学Greta Snellman教授及其团队进行了一项研究，该研究发现饮食维生素D摄入在骨折和骨质疏松的发生中居次要地位。该研究结果在线发表在2013年12月11日的The Journal of Clinical Endocrinology &am

膳食中维生素D在预防骨质疏松性骨折中的重要性尚不确定。为了探讨饮食中维生素D摄入与骨折和骨质疏松风险之间的关系，来自瑞典乌普萨拉大学Greta Snellman教授及其团队进行了一项研究，该研究发现饮食维生素D摄入在骨折和骨质疏松的发生中居次要地位。该研究结果在线发表在2013年12月11日的The Journal of Clinical Endocrinology & Metabolism杂志上。【原文下载】

该研究中，在基于人群的瑞典Mammography队列中（包括61433例女性受试者，随访19年），通过重复的食物频率问卷评估饮食。该研究在瑞典中部的两个直辖市进行。从登记信息中确定骨折的发生。在一个亚队列中（5022例受试者），使用DXA测量骨密度（BMD），使用HPLC-MS/MS测量S-25（OH）D.该研究结果表明，随访期间，14738例女性受试者首次发生任一类型的骨折，而且3871例受试者为髋部骨折。与维生素D摄入第三五分位数受试者相比，维生素D摄入最低五分位数和最高五分位数的受试者首次发生任一类型骨折的多元校正风险比（HR）为0.96和1.02.维生素D摄入最低五分位数和最高五分位数受试者相应的首次髋部骨折HR为1.02和1.14.与维生素D每日摄入小于5ug受试者相比，维生素D每日摄入大于10ug受试者任一类型的骨折HR为1.02，髋部骨折HR为1.27.尽管较高水平的维生素D摄入与较高的BMD相关，但是维生素D摄入不影响骨质疏松发生。该研究观察到维生素D摄入与S-25（OH）D之间呈正相关。

该研究发现，在瑞典社区女性居民中，饮食维生素D摄入在骨折和骨质疏松的发生中居次要地位。

研究背景：大部分女士和男士在他们一生中会经历一次以上的骨质疏松性骨折。而且，全世界髋部骨折的发生率预计在2050年将增加大约四倍。因此，骨折预防非常重要。维生素D在骨骼矿化中有非常重要的作用，维生素D可以促进饮食中钙吸收，而且对甲状旁腺激素的分泌有负反馈作用。因此，维生素D缺乏可以导致骨骼中钙丢失，并最终导致骨质疏松和骨折。

原文出处：

Greta Snellman, Liisa Byberg, Eva Warensjö Lemming, Håkan Melhus, Rolf Gedeborg, Hans Mallmin, Alicja Wolk and Karl Michaëlsson.Long-term dietary vitamin D intake and risk of fracture and osteoporosis: a longitudinal cohort study of Swedish middle-aged and elderly women.The Journal of Clinical Endocrinology & Metabolism December 11, 2013 jc.2013-1738【原文下载】

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2014-01-18 achengzhao

#JCE#

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2014-03-26 smallant2015

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2013-12-20 ms9651749636653578

#骨质疏松性骨折#

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2013-12-20 Eleven17

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