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Pediatrics:极早产儿在学龄期易发生认知功能损害

2016-05-30 phylis 译 MedSci原创

背景:尽管极早产儿的死亡率和发病率有所降低,他们发生神经认知功能缺陷的风险较高,高达40%的孩子在学龄期有明显的认知功能障碍。研究者应用当代美国873个10岁孩子的队列,评估其神经认知功能损害率,这些孩子在孕28周内出生。方法:2002年到2004年,在5个州的14个地区招募889个家庭中的966个(92%)孩子,在孩子10岁时,进行IQ,语言,注意力,执行功能,处理速度,视觉感知,视觉运动功能,

背景:尽管极早产儿的死亡率和发病率有所降低,他们发生神经认知功能缺陷的风险较高,高达40%的孩子在学龄期有明显的认知功能障碍。研究者应用当代美国873个10岁孩子的队列,评估其神经认知功能损害率,这些孩子在孕28周内出生。

方法:2002年到2004年,在5个州的14个地区招募889个家庭中的966个(92%)孩子,在孩子10岁时,进行IQ、语言、注意力、执行功能、处理速度、视觉感知、视觉运动功能、学术成就的综合评估。

结果:总共有873名儿童进行了良好效度的认知和学术成就的综合评估。测试成绩的分布是一致的,并且显著低于常模。三分之一到三分之二的儿童低于相同年龄值的一个SD。执行功能和处理速度是下降最多的。校正社会经济地位,生长受限及其他潜在的混杂因素后,多变量分析发现在在所有18项检测中,最低胎龄不良预后的风险是最高的。

结论:队列中超过一半以上的极早产儿在10岁时,出现中度或严重的神经认知功能障碍,在那些最低胎龄的孩子,损害越严重。极早产儿神经认知功能和学术成绩持续损害的风险较高,在幼儿期应强调监测和修复这些不良结果。

原始出处:

Joseph RM, O'Shea TM, et al. Neurocognitive and Academic Outcomes at Age 10 Years of Extremely Preterm Newborns. Pediatrics. 2016 Mar 22.


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    2017-02-28 hbwxf
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    2016-06-07 feather89
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    2016-06-15 早茶月光

    之前一篇文献说过期儿有利于认知功能但有其他风险。。。看来还是足月儿比较安全

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1958473, encodeId=3f4319584e397, content=<a href='/topic/show?id=766713993a1' target=_blank style='color:#2F92EE;'>#Pediatric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13993, encryptionId=766713993a1, topicName=Pediatric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Feb 28 07:43:00 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726113, encodeId=9c941e2611393, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Jun 07 04:43:00 CST 2016, time=2016-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637358, encodeId=9024163e3582e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Mar 30 19:43:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89916, encodeId=e0f7899165c, content=之前一篇文献说过期儿有利于认知功能但有其他风险。。。看来还是足月儿比较安全, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160704/IMG577A7DF6CC7185344.jpg, createdBy=07531689549, createdName=早茶月光, createdTime=Wed Jun 15 09:25:00 CST 2016, time=2016-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457039, encodeId=4014145e0392e, content=<a href='/topic/show?id=09bd61685aa' target=_blank style='color:#2F92EE;'>#极早产儿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61685, encryptionId=09bd61685aa, topicName=极早产儿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=521c5837609, createdName=wmr113, createdTime=Wed Jun 01 12:43:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87900, encodeId=d1be8e90002, content=不容易,小宝贝, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:04:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-05-31 足球疯子

    不容易,小宝贝

    0

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