JAHA：代谢综合征对死亡率的影响可受睡眠时间的调节！

2017-05-20 xing.T MedSci原创

由此可见，睡眠持续时间较短的个人与代谢综合征相关的死亡风险增加。代谢综合征患者短暂睡眠可能与更大的中枢自主神经和代谢功能障碍有关。未来的临床试验应评估延长睡眠是否可以改善代谢综合征个人的预后。

近日，心血管疾病领域权威杂志JAHA上发表了一篇研究文章，研究人员旨在评估客观睡眠时间是否是代谢综合征对全因和心血管疾病/脑血管死亡影响的效应修饰因素。

研究人员采用宾夕法尼亚州成人队列来解决这个问题，该队列是一个随机的一般人群样本，共有1344名男性和女性（48.8±14.2岁），他们在睡眠实验室进行了研究，并随访了16.6±4.2年。代谢综合征定义为在肥胖（≥30公斤/平方米）、高总胆固醇（≥200毫克/分升）、高甘油三酯（≥150毫克/分升）、高空腹血糖（≥100毫克/分升）和高血压（≥130/85mmHg）因素中包含3项以上。多导睡眠时间分为有临床意义的类别。

在1344名参与者中，22%的参与者在随访期间死亡。研究人员采用控制了多个潜在的混杂因素的Cox比例风险模型评估代谢综合征和多导睡眠时间与死亡率之间的相互作用（P＜0.05）。与代谢综合征相关的全因和心血管疾病/脑血管死亡风险比（95%可信区间）对于睡眠时间＞6小时的个人分别为1.29（0.89-1.87）和1.49（0.75-2.97），在睡眠时间＜6小时的个人中分别为1.99（1.53-2.59）和2.10（1.39-3.16）。有趣的是，这种效应的调整主要是由代谢综合征中血压升高和葡萄糖失调驱动的。

由此可见，睡眠持续时间较短的个人与代谢综合征相关的死亡风险增加。代谢综合征患者短暂睡眠可能与更大的中枢自主神经和代谢功能障碍有关。未来的临床试验应评估延长睡眠是否可以改善代谢综合征个人的预后。

原始出处：

Julio Fernandez‐Mendoza, et al. Impact of the Metabolic Syndrome on Mortality is Modified by Objective Short Sleep Duration.JAHA.2017. https://doi.org/10.1161/JAHA.117.005479

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2017-05-27 惠映实验室

疾病与疾病相关性研究？

91 0
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2017-05-24 doctorJiangchao

继续学习。

0 0
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2017-05-24 一个字-牛

好文章，学习了！

112 0
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2017-05-22 医者仁心

#AHA#

60 0
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2017-05-22 zhouqu_8

#综合征#

51 0
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2017-05-22 1e10c84am36(暂无匿称)

文章真好，拜读了

99 0
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2017-05-21 杨利洪

学习并分享了

0 0
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