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Prev Med:抑郁症状或可影响10年内急性冠脉综合征发生率

2016-05-12 MedSci MedSci原创

一项发表于preventive medicine的研究发现,急性冠脉综合征(ACS)患者合并严重抑郁状态可显著增加其10年内心血管疾病(CVD)的发生率。该研究为前瞻性多中心研究,连续纳入自2003年10月至2004年9月就诊于6家希腊医院的2172名ACS患者,进行为期10年的随访。使用经过验证的CES-D评分量表(0-60分)评估抑郁症状,通过地中海饮食评分(MedDietScore,0-55

一项发表于preventive medicine的研究发现,急性冠脉综合征(ACS)患者合并严重抑郁状态可显著增加其10年内心血管疾病(CVD)的发生率。

该研究为前瞻性多中心研究,连续纳入自2003年10月至2004年9月就诊于6家希腊医院的2172名ACS患者,进行为期10年的随访。使用经过验证的CES-D评分量表(0-60分)评估抑郁症状,通过地中海饮食评分(MedDietScore,0-55分)评估地中海式饮食依从性,财务状况由年收入确定。

Notara V博士等人根据CES-D评分结果将患者分为无抑郁、轻度抑郁、重度抑郁3组,研究结果显示,各组致死/非致死性ACS复发率分别为33%,37%和42%(P = 0.006)。多元Logistic回归模型表明,相比无抑郁组,重度抑郁组与10年致死/非致死性ACS事件相关[比值比(OR)=1.31, 95%CI 1.01-1.69]。经校正患者财务状况,抑郁症与ACS预后间的关联仍显著存在,亚组分析结果表明,仅对低/中收入患者造成负面影响(OR =1.36,95%CI 0.98-1.88)。通过MedDietScore得分进一步分层分析,结果表明,上述关联只在地中海饮食依从性低的患者中显著存在(OR = 1.68,95%CI 1.10-2.18)。

研究结果表明,ACS患者合并严重抑郁症状态或可导致不良疾病预后,财务状况与地中海饮食可能是潜在的调节因素。研究人员指出,公共卫生项目应重点关注易感群体,通过适当的药物治疗与生活方式进行干预,以便尽可能的改善抑郁症状,从而在临床以及社区层面改善疾病的预后情况。


原始出处:

Notara V, Panagiotakos DB, Tsompanaki E, Kouvari M, Kogias Y, Papanagnou G, Antonoulas A, Stravopodis P, Zombolos S, Stergiouli I, Mantas Y, Babatsikou F, Pitsavos C; GREECS Study Investigators, Greece. Depressive symptomatology in relation to 10-year (2004-2014) acute coronary syndrome incidence; the moderating role of diet and financial status. Prev Med. 2016 May;86:6-11

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    2016-10-06 1e10c84am36(暂无匿称)

    文章真心很好,感谢作者

    0

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布莱根女性医院(BWH)的研究人员指出,接受ADT疗法的局限性前列腺癌患者会增加患抑郁症的风险,研究结果发表在the Journal of Clinical Oncology。 哈佛医学院放射肿瘤学副教授Paul Nguyen解释说,男性前列腺癌(PCa)患者由于接受ADT治疗会导致性功能减退、体重增加和乏力等,这些都会导致民众出现抑郁。他指出,深入调查后,他发现PCa患者采用ADT疗法与抑郁明显

ADAA 2016:抑郁焦虑初级保健患者,将受益于计算机化CBT

2016年美国焦虑和抑郁学会年会称,伴有抑郁和焦虑症状的初级保健患者,将受益于计算机化的认知行为治疗方案(CBT)。匹兹堡大学医学院的Bea Herbeck Belnap博士和同事对603名伴有抑郁和焦虑症状的初级保健患者进行了研究。在超过6个月的时间里,计划让患者完成8个长达50分钟的计算机化CBT。数据显示,实际上患者平均完成了5.3次计算机化CBT治疗。白种人与非白种人相比,更有可能完成整个

J Neurosci:压力如何损伤你的大脑、破坏记忆、引起抑郁?

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Am J Gastroenterol:抑郁会加重克罗恩病?

克罗恩病(CD)患者的抑郁发生率较高,研究者进行了一项研究,探究抑郁情感认知症状对CD恶化风险的影响。该研究纳入了2144名CD患者,在基线时完成人口统计学、CD状况和抑郁情感认知指数等调查。使用线性和逻辑回归分析12个月时的CD状况是否与基线抑郁相关。研究中对患者年龄、性别、种族、基线疾病活动、疾病持续时间、住院和手术、皮质类固醇和抗肿瘤坏死因子的使用、药物依从性、BMI、目前吸烟、教育和睡眠质

Nature:挑战常规!揭示氯胺酮抗抑郁作用机制

在一项新的研究中,来自美国国家卫生研究院(NIH)等多个机构的研究人员发现机体降解氯胺酮(ketamine)产生的一种代谢物可能是它的速效性抗抑郁作用的真正秘密。这种代谢物显著地逆转小鼠的类似抑郁的行为,同时不会触发与氯胺酮相关联的麻醉性、解离性或上瘾的副作用。相关研究结果2016年5月4日在线发表在Nature期刊上,论文标题为“NMDAR inhibition-independent

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