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Circulation :先天性心脏疾病:儿童异常发育的高危因素

2015-09-01 张旭栋 MedSci原创

威斯康星医学院(密尔沃基),Mussatto KA等人研究了先天性心脏疾病对儿童异常发育的影响,研究成果发表在8月份Circulation期刊上。背景:先天性心脏疾病会导致儿童发育迟缓。本研究旨在明确患有先天性心脏疾病的儿童其异常发育的早期影响因素。方法和结果:先天性心脏疾病(没有已知的遗传异常)是儿童发育迟缓(贝利婴幼儿发育量表-III >3分)的高风险因素。对临床因素如认知,语言,以及运

威斯康星医学院(密尔沃基),Mussatto KA等人研究了先天性心脏疾病对儿童异常发育的影响,研究成果发表在8月份Circulation期刊上。

背景:先天性心脏疾病会导致儿童发育迟缓。本研究旨在明确患有先天性心脏疾病的儿童其异常发育的早期影响因素。

方法和结果:先天性心脏疾病(没有已知的遗传异常)是儿童发育迟缓(贝利婴幼儿发育量表-III >3分)的高风险因素。对临床因素如认知,语言,以及运动能力进行Logistic分析,从而评估先天性心脏疾病对患者的影响程度,并对其进行分类:发育正常或改善,≥85分(低于平均数1个标准差),或≥85分并不再降低;发育不正常,<85分,或<85并不再升高,或在85分上下浮动。通过贝利婴幼儿发育量表-III评估了131例儿童(年龄在5.5-37.4个月之间)发育情况。56%儿童的认知,语言,运动能力在正常范围内。23%儿童单域发育延迟,21%儿童多域发育延迟。更多心脏手术,住院时间延长,较差的线性增长,管喂养在所有单域中显示结果较差(P <0.05)。多变量模型显示,管喂养是异常发育的一项危险因素(比值比:5.1-7.9)。少数族裔和缺乏私人保险的患者与单域有着密切的联系。

结论:纵向发育监测显示,随着时间的推移,早期影响因子能够定量发育迟缓。治疗策略改善可改变因素和早期干预治疗可减少儿童发育迟缓风险。

原始出处:

Mussatto KA, Hoffmann R, Hoffman G, Tweddell JS, Bear L, Cao Y, Tanem J, Brosig C (2015) Risk Factors for Abnormal Developmental Trajectories in Young Children With Congenital Heart Disease. Circulation 132 (8):755-761. doi:10.1161/circulationaha.114.014521

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    2015-09-03 neurowu
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    2015-09-03 huirong
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