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CSCO 2016:软组织肉瘤的放疗研究一览

2016-09-26 MedSci MedSci原创

2016年9月22日-24日,第19届全国临床肿瘤学大会暨2016年CSCO学术年会在福建厦门国际会议中心举行。在本届CSCO中,来自中国医学科学院附属肿瘤医院放疗科的房辉和王维虎老师带来了题为《软组织肉瘤的放疗》的精彩报告,下面是梅斯医学小编对其内容的整理:一、放疗的证据最早刊发在1982年Ann surg上2个放疗的随机研究证明了放疗治疗的可取,如下图所示:另,1996年发表在JCO上的一项放

2016年9月22日-24日,第19届全国临床肿瘤学大会暨2016年CSCO学术年会在福建厦门国际会议中心举行。在本届CSCO中,来自中国医学科学院附属肿瘤医院放疗科的房辉和王维虎老师带来了题为《软组织肉瘤的放疗》的精彩报告,下面是梅斯医学小编对其内容的整理:


一、放疗的证据

最早刊发在1982年Ann surg上2个放疗的随机研究证明了放疗治疗的可取,如下图所示:


另,1996年发表在JCO上的一项放疗随机研究(MSKCC近距离放疗):



二、放疗的实施

1.时序:术前放疗、术后放疗
2.方式:外照射、内照射(近距离照射)
3.技术:常规2维技术、3维精确放疗(试行放疗、调强放疗等)

相比术后放疗,术前放疗的优点:照射范围小(不必包括手术野)、减少手术引起的肿瘤种植、放疗剂量低(一般50Gy)、肿瘤氧合好、提高切除率。(如下图所示)

(2002年发表在Lancet上的一项对12190例患者随机分组,术前放疗对比术后放疗的研究结果显示:术后120天内)

但是另一项观察长期预后的研究显示:

(术后2年晚期并发症)

1.辅助放疗(SSG)

(1093例四肢和躯干STS,中位随访5年,5年局部控制率)

2.腹膜后肉瘤(RPS)放疗

盘点了8篇近十年来有关RPS放疗的研究,分别如下图所示:












(440例高分化RPS)





3.STS放疗同步化疗或靶向

共6篇研究,分别如下图所示:







4.STS常规与调强疗效比较

研究一:
(四肢原发STS术后放疗:154例常规vs 165里调强)

放疗后的大于2级的毒副反应情况:与常规组相比,调强组放射性皮炎(48.7% vs 31.5%,P=0.002)、水肿(14.9% vs 7.9%,P=0.05)更少,关于僵硬(11.0% vs 14.5%,P=0.40)情况相似。

研究二:

5.四肢STS术前IGRT

(2年总生存率:80.6%;2年无病生存率:58.1%;2年无远转病生存率:61.4%)

总结:

1.软组织肉瘤术前放疗是发展的趋势;
2.放疗新技术的应用提高了局部控制率,降低了放疗的晚期毒副作用
3.放疗同步化疗或靶向药物疗效需进一步研究

更多关于CSCO 2016的最新报道,请点击活动:CSCO 2016

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2016-09-28 oo902

    谢谢分享,csco

    0

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    2016-09-28 qilu_qi
  3. [GetPortalCommentsPageByObjectIdResponse(id=137092, encodeId=58c213e09229, content=谢谢分享,csco, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Sep 28 18:40:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420382, encodeId=49dd14203823a, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Wed Sep 28 07:06:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135561, encodeId=bcbf1355614d, content=非常值得学习,要重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd381919282, createdName=1e0a2178m68(暂无匿称), createdTime=Mon Sep 26 20:53:55 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135542, encodeId=dd8613554228, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Mon Sep 26 20:23:47 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135541, encodeId=de11135541a7, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Mon Sep 26 20:23:32 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135470, encodeId=7f961354e086, content=学习了,赞一个~, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160905/IMG57CD39B82D12E7926.jpg, createdBy=ac2c1946830, createdName=青龙偃月, createdTime=Mon Sep 26 16:51:00 CST 2016, time=2016-09-26, status=1, ipAttribution=)]
    2016-09-26 1e0a2178m68(暂无匿称)

    非常值得学习,要重视

    0

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    2016-09-26 知难而进

    继续关注!

    0

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    2016-09-26 知难而进

    谢谢分享!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=137092, encodeId=58c213e09229, content=谢谢分享,csco, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Sep 28 18:40:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420382, encodeId=49dd14203823a, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Wed Sep 28 07:06:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135561, encodeId=bcbf1355614d, content=非常值得学习,要重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd381919282, createdName=1e0a2178m68(暂无匿称), createdTime=Mon Sep 26 20:53:55 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135542, encodeId=dd8613554228, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Mon Sep 26 20:23:47 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135541, encodeId=de11135541a7, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Mon Sep 26 20:23:32 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135470, encodeId=7f961354e086, content=学习了,赞一个~, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160905/IMG57CD39B82D12E7926.jpg, createdBy=ac2c1946830, createdName=青龙偃月, createdTime=Mon Sep 26 16:51:00 CST 2016, time=2016-09-26, status=1, ipAttribution=)]
    2016-09-26 青龙偃月

    学习了,赞一个~

    0

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