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Arch Gynecol Obstet:β-地中海贫血孕妇分娩出低出生体重儿的风险增加

2015-10-26 徐媛 MedSci原创

本研究比较了患有β-地中海贫血的孕妇与正常孕妇的分娩预后。在这项回顾性队列研究中,研究人员收纳了单胎合并β地中海贫血的孕妇以及正常孕妇,并将受试者按照2:1的比例随机分配到对照组和研究组。所收纳的受试者都是低危妊娠,没有潜在的内科疾病和胎儿畸形疾病。接受侵入性产前诊断的孕妇被排除在外。本研究共纳入597例地中海贫血孕妇和1194例正常孕妇。两组的基线特征和分娩预后都相似,除了研究组的血红蛋白水平稍

本研究比较了患有β-地中海贫血的孕妇与正常孕妇的分娩预后。

在这项回顾性队列研究中,研究人员收纳了单胎合并β地中海贫血的孕妇以及正常孕妇,并将受试者按照2:1的比例随机分配到对照组和研究组。所收纳的受试者都是低危妊娠,没有潜在的内科疾病和胎儿畸形疾病。接受侵入性产前诊断的孕妇被排除在外。

本研究共纳入597例地中海贫血孕妇和1194例正常孕妇。两组的基线特征和分娩预后都相似,除了研究组的血红蛋白水平稍低。在研究组,胎龄小和早产儿的出生率更高,但没有达到显著水平,并且低出生体重儿的发生率也明显较高(相对风险 1.25; 95 % CI 1.00-1.57)。此外,在研究组中,堕胎率也明显高于对照组(相对风险 3.25,95%可信区间1.35 - -7.80)。

β-地中海贫血孕妇分娩出低出生体重的风险增加,但并没有增加孕妇分娩后不良预后发生率。

原始出处

Charoenboon C1, Jatavan P1, Traisrisilp K1, Tongsong T2.Pregnancy outcomes among women with beta-thalassemia trait.Arch Gynecol Obstet. 2015 Oct 17

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    2016-09-10 yhy100200
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    2015-10-28 linlin2312
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    2015-10-28 wgx311
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    2015-10-26 lixh1719

    不知道远期如何

    0

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