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Langmuir:氧化石墨烯(GO)和溶菌酶(Lys)超薄膜具有很强的抗菌和增强的成骨作用

2019-04-30 不详 网络

全世界对骨相关植入材料的需求很大。慢性感染和当前植入材料的骨愈合不良限制了其临床应用。在植入材料上用抗菌和成骨膜功能化植入物表面为制造新型植入物材料提供了新的机会。在本研究中,研究人员使用逐层(LBL)技术以及GO和溶菌酶的替代沉积来制造几十纳米的超薄(GO/Lys)8膜。椭圆光度法,紫外-可见光和傅立叶变换红外(FTIR)检测显示(GO/Lys)n薄膜的沉积呈现连续生长,并使用原子力显微镜(AF

全世界对骨相关植入材料的需求很大。慢性感染和当前植入材料的骨愈合不良限制了其临床应用。在植入材料上用抗菌和成骨膜功能化植入物表面为制造新型植入物材料提供了新的机会。

在本研究中,研究人员使用逐层(LBL)技术以及GO和溶菌酶的替代沉积来制造几十纳米的超薄(GO/Lys)8膜。椭圆光度法,紫外-可见光和傅立叶变换红外(FTIR)检测显示(GO/Lys)n薄膜的沉积呈现连续生长,并使用原子力显微镜(AFM)表征该薄膜的物理性质(形态,粗糙度和刚度)。

结果显示,超薄膜对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌的灭菌效果明显,并提高了成骨分化效率,显示了其在骨植入物涂层中的潜在应用。我们相信这种逐层组装策略将为制造双功能表面铺平道路,并指导未来植入表面的设计。

原始出处:

Li M, Li H, et al., Graphene oxide (GO) and lysozyme (Lys) ultrathin film with strong antibacterial and enhanced osteogenesis. Langmuir. 2019 Apr 27. doi: 10.1021/acs.langmuir.9b00035.

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