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Lancet:手部巨大痛风结石案例报道

2016-06-28 MedSci MedSci原创

59岁女性,因关节多发结节,就诊于上海交通大学附属瑞金医院。

59岁女性,因关节多发结节,就诊于上海交通大学附属瑞金医院。

曾行关节腔穿刺检查可见负性双折射晶体,诊断为痛风性关节炎。规律服用别嘌呤醇、苯溴马隆。除此之外,患有2型糖尿病。

体格检查显示多发性痛风结节(耳廓、膝关节、踝关节、手、足趾关节);在手部尤为突出(见图),手部灵活性和伸展性严重丧失。

生化检查示,肌酸升高(137μmol/L,正常范围62–115 μmol/L),尿酸升高(725 μmol/L; 正常范围 208–428 μmol/L)。诊断为晚期侵蚀性沙粒状痛风,给予非布索坦治疗降低尿酸浓度。经过一个月的治疗后,尿酸降低到578 μmol/L。之后,患者不愿意再进行尿酸检测或手术治疗。结果,我们不知道患者目前的尿酸值。


59岁女性手部巨大痛风结石

痛风是一种常见的代谢性疾病,由外周关节的尿酸盐结晶沉积引起。软组织中的尿酸盐结晶沉积形成结石,常见于跖趾关节或膝盖。然而,痛风结石沉积在手上是不常见的。结石通常出现在有痛风性关节炎病史10年以上的患者中。主要治疗是使用抗高尿酸药物,理想的痛风结石吸收的浓度是低于357 mmol/L。手术移除结石可减少疼痛,使功能最大化并提高美观。

原始出处:

Bing Han, MD, Liqiong Xue, MD, Dr Chengde Yang, MD,et al,Giant gouty tophi in the hands,lancet,Published Online: 19 February 2016


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    2016-11-13 howi
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    2016-09-14 ylzr123

    关注值得,学习。赞!好文探究。

    0

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    2016-07-12 水蓝

    好可怕

    0

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    2016-07-10 oo902

    学习了,好文章

    0

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    2016-06-30 hl573567

    写的真好

    0

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    2016-06-29 milkshark

    这个不错

    0

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    2016-06-29 milkshark

    真的好文章

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1828526, encodeId=d549182852698, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Nov 13 17:45:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126613, encodeId=9d62126613e8, content=关注值得,学习。赞!好文探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 14 13:24:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92839, encodeId=16c392839e1, content=好可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eda01744303, createdName=水蓝, createdTime=Tue Jul 12 15:59:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92524, encodeId=7fba925245c, content=学习了,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 10 09:06:00 CST 2016, time=2016-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91611, encodeId=b2d0916115f, content=写的真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160611/IMG575BDDE29B42C3218.jpg, createdBy=5c861626135, createdName=hl573567, createdTime=Thu Jun 30 07:12:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91548, encodeId=a72391548bb, content=这个不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:20:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91549, encodeId=84b791549f9, content=真的好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:20:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91538, encodeId=72029153833, content=不错,没见过, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yqGyqlRsWYXXlASPpCvDxQIOj4U5ibyTGicNR5nTPxfE7J8CJLYEoTQiax0mdQk45PFsUH94hHxH18w/0, createdBy=96eb98305, createdName=qixiaotong123, createdTime=Wed Jun 29 08:54:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91534, encodeId=7afc9153469, content=少见,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Jun 29 08:14:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91533, encodeId=200491533bf, content=真的好大!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 29 08:10:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-06-29 qixiaotong123

    不错,没见过

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1828526, encodeId=d549182852698, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Nov 13 17:45:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126613, encodeId=9d62126613e8, content=关注值得,学习。赞!好文探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 14 13:24:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92839, encodeId=16c392839e1, content=好可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eda01744303, createdName=水蓝, createdTime=Tue Jul 12 15:59:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92524, encodeId=7fba925245c, content=学习了,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 10 09:06:00 CST 2016, time=2016-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91611, encodeId=b2d0916115f, content=写的真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160611/IMG575BDDE29B42C3218.jpg, createdBy=5c861626135, createdName=hl573567, createdTime=Thu Jun 30 07:12:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91548, encodeId=a72391548bb, content=这个不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:20:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91549, encodeId=84b791549f9, content=真的好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:20:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91538, encodeId=72029153833, content=不错,没见过, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yqGyqlRsWYXXlASPpCvDxQIOj4U5ibyTGicNR5nTPxfE7J8CJLYEoTQiax0mdQk45PFsUH94hHxH18w/0, createdBy=96eb98305, createdName=qixiaotong123, createdTime=Wed Jun 29 08:54:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91534, encodeId=7afc9153469, content=少见,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Jun 29 08:14:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91533, encodeId=200491533bf, content=真的好大!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 29 08:10:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-06-29 深海的鱼

    少见,学习了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1828526, encodeId=d549182852698, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Nov 13 17:45:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126613, encodeId=9d62126613e8, content=关注值得,学习。赞!好文探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 14 13:24:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92839, encodeId=16c392839e1, content=好可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eda01744303, createdName=水蓝, createdTime=Tue Jul 12 15:59:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92524, encodeId=7fba925245c, content=学习了,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 10 09:06:00 CST 2016, time=2016-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91611, encodeId=b2d0916115f, content=写的真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160611/IMG575BDDE29B42C3218.jpg, createdBy=5c861626135, createdName=hl573567, createdTime=Thu Jun 30 07:12:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91548, encodeId=a72391548bb, content=这个不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:20:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91549, encodeId=84b791549f9, content=真的好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:20:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91538, encodeId=72029153833, content=不错,没见过, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yqGyqlRsWYXXlASPpCvDxQIOj4U5ibyTGicNR5nTPxfE7J8CJLYEoTQiax0mdQk45PFsUH94hHxH18w/0, createdBy=96eb98305, createdName=qixiaotong123, createdTime=Wed Jun 29 08:54:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91534, encodeId=7afc9153469, content=少见,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Jun 29 08:14:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91533, encodeId=200491533bf, content=真的好大!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jun 29 08:10:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-06-29 1dd8c52fm63(暂无匿称)

    真的好大!

    0

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