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Heart:心血管磁共振预测三尖瓣Ebstein氏畸形患者的主要不良事件和房性心动过速!

2017-07-10 xing.T MedSci原创

由此可见,CMR衍生的指标携带了未经治疗的EA成年人MACE和首发AT的预后信息。CMR可能被纳入在这些患者的定期监视的手段中。

三尖瓣Ebstein氏畸形(EA)的患者具有快速性心律失常、充血性心力衰竭和心源性猝死的风险。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员试图明确心血管磁共振(CMR)在预测这些结局中的价值。

研究人员纳入了79例连续就诊的成年患者(年龄为37±15岁),这些且尚未接受治疗的EA患者进行CMR检查,对其临床结局进行性前瞻性地中位随访3.4年(范围为0.4-10.9年),即主要不良心血管事件(MACEs:持续室性心动过速/心力衰竭住院/心脏移植/死亡)和首发性房性快速性心律失常(AT)。

研究人员发现与MACE相关的CMR衍生变量(n=6)为右心室(RV)或左室射血分数(EF)(风险比为2.06,95%可信区间为1.168至3.623,P=0.012;风险比为2.35,95%可信区间为1.348至4.082,P=0.003),左室卒中体积指数(风险比为2.82,95%可信区间为1.212-7.092,P=0.028)和心脏指数(风险比为1.71,95%可信区间为1.002至1.366,P=0.037);当仅对死亡率进行检验时,所有均具有显著性。AT病史(风险比为11.16,95%可信区间为1.30至95.81,P=0.028)和纽约心脏协会分级>2(风险比为7.66,95%可信区间为1.54至38.20,P=0.013)也与MACE相关;除了一个MACE之外,AT均发生在所有MACE之前,这表明其具有作为不良结局早期标志物的潜在作用(P=0.011)。

研究人员还发现CMR变量与首发AT存在相关性(n=17; 21.5%),包括RVEF(风险比为1.55,95%可信区间为1.103至2.160,P=0.011),总R/L体积指数(风险比为1.18,95%可信区间为1.06至1.32,P=0.002),RV/LV舒张末期容积比(风险比为1.55,95%可信区间为1.14至2.10,P=0.005)和心尖瓣隔叶位移/总LV间隔长度(风险比为1.03,95%可信区间为1.00至1.07,P=0.041);后两者结合增强的风险预测(风险比为6.12,95%可信区间为1.67至22.56,P=0.007)。

由此可见,CMR衍生的指标携带了未经治疗的EA成年人MACE和首发AT的预后信息。CMR可能被纳入在这些患者的定期监视的手段中。

原始出处:

Riikka Rydman,et al. Major adverse events and atrial tachycardia in Ebstein’s anomaly predicted by cardiovascular magnetic resonance. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-311274

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    2017-07-12 zhaojie88
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    2017-07-12 wushaoling
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    2017-07-12 slcumt
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