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Clin Exp Rheumatol:强直性脊柱炎患者的骨折风险高

2016-05-29 Seven L MedSci原创

有研究结果表明,活动性强直性脊柱炎患者有较高的放射学上的椎体骨折患病率。173名强直性脊柱炎患者中有105名使用了肿瘤坏死因子-α(TNF-α)阻断治疗4年。对患者的基线和4年随访数据进行分析。结果显示,在基线时有影像学椎体骨折的占26%。研究人员指出,这些患者更老、枕墙距更大和更多的脊柱放射学损害。4年的TNF-α阻断治疗期间,有20%的患者经历了至少1次新骨折。研究者发现新骨折的发生与年龄、吸

有研究结果表明,活动性强直性脊柱炎患者有较高的放射学上的椎体骨折患病率。

173名强直性脊柱炎患者中有105名使用了肿瘤坏死因子-α(TNF-α)阻断治疗4年。对患者的基线和4年随访数据进行分析。

结果显示,在基线时有影像学椎体骨折的占26%。研究人员指出,这些患者更老、枕墙距更大和更多的脊柱放射学损害。4年的TNF-α阻断治疗期间,有20%的患者经历了至少1次新骨折。研究者发现新骨折的发生与年龄、吸烟、高强直性脊柱炎功能指数、低腰椎骨密度(BMD)、中度椎体骨折的存在和使用抗骨质疏松治疗有关。

研究人员发现,大多数骨折都是轻度的,发生在胸椎,新骨折患者在治疗过程中,腰椎活动度和腰椎骨密度明显更少。

“临床医生应该了解强直性脊柱炎患者在进行TNF-α阻断治疗时,出现椎体骨折是常有的,与较差的预后有关。”荷兰格罗宁根大学医学中心的Fiona Maas博士说。

原始出处:

Maas F, et al.Radiographic vertebral fractures develop in patients with ankylosing spondylitis during 4 years of TNF-α blocking therapy.Clin Exp Rheumatol. 2016;34:191-199.

High prevalence of radiographic vertebral fractures found among patients with ankylosing spondylitis
.Healio.May 27, 2016

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1946823, encodeId=cc9c194682341, content=<a href='/topic/show?id=9a3950183e9' target=_blank style='color:#2F92EE;'>#强直性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50183, encryptionId=9a3950183e9, topicName=强直性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKeia4TJeMGvEH3wKKIBNjuHuIic1HDNOB10j4tCd3nbylxkxm6HSMfEaKkSu6OZOak4uZv7UVicsWEg/132, createdBy=bc9a2500116, createdName=zywlvao, createdTime=Thu Feb 23 11:32:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129435, encodeId=b464129435b2, content=不错哦,会学到很多,喜欢梅斯医学文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 17 11:47:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390349, encodeId=4015139034948, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Tue May 31 08:32:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440331, encodeId=ea2114403310a, content=<a href='/topic/show?id=6f0e845427f' target=_blank style='color:#2F92EE;'>#脊柱炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84542, encryptionId=6f0e845427f, topicName=脊柱炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50834728424, createdName=1249898am16暂无昵称, createdTime=Tue May 31 08:32:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87698, encodeId=f06c8e69880, content=这是事实, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Tue May 31 05:40:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2017-02-23 zywlvao
  2. [GetPortalCommentsPageByObjectIdResponse(id=1946823, encodeId=cc9c194682341, content=<a href='/topic/show?id=9a3950183e9' target=_blank style='color:#2F92EE;'>#强直性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50183, encryptionId=9a3950183e9, topicName=强直性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKeia4TJeMGvEH3wKKIBNjuHuIic1HDNOB10j4tCd3nbylxkxm6HSMfEaKkSu6OZOak4uZv7UVicsWEg/132, createdBy=bc9a2500116, createdName=zywlvao, createdTime=Thu Feb 23 11:32:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129435, encodeId=b464129435b2, content=不错哦,会学到很多,喜欢梅斯医学文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 17 11:47:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390349, encodeId=4015139034948, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Tue May 31 08:32:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440331, encodeId=ea2114403310a, content=<a href='/topic/show?id=6f0e845427f' target=_blank style='color:#2F92EE;'>#脊柱炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84542, encryptionId=6f0e845427f, topicName=脊柱炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50834728424, createdName=1249898am16暂无昵称, createdTime=Tue May 31 08:32:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87698, encodeId=f06c8e69880, content=这是事实, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Tue May 31 05:40:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-09-17 1e10c84am36(暂无匿称)

    不错哦,会学到很多,喜欢梅斯医学文章

    0

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    2016-05-31 老段

    这是事实

    0

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背景:曾有数据显示依那西普的水平与类风湿关节炎患者的临床反应有相关性。然而,对于强直性脊柱炎而言,针对类风湿关节炎的研究数据显然是不够合理的。目的:研究依那西普水平与AS病患临床反应之间的关系。方法:前瞻性观察队列研究,招募162例以依那西普治疗的强直性脊柱炎患者,观察其24周的治疗情况。依那西普的水平使用ELISA回顾性检测。疾病活动性使用强施行脊柱炎活动评分(ASDAS)评估,另外包括测定C-

Ann Rheum Dis:母乳喂养可预防强直性脊柱炎

目的:强直性脊柱炎患者(AS)是一种影响年轻患者的脊柱和骨盆的慢性炎性疾病。在HLA-B27的遗传背景下,AS的发生与肠道微生物群有相关性。而我们研究的目标是试验母乳喂养影响肠道菌群,以此可以阻止AS的发展。方法:第一,在风湿免疫科招募203例符合修改后的纽约标准、HLA-B27阳性的患者。在这些AS患者的家族中招募了总共293例健康兄妹作为对照组。第二,280例健康对照组,和招募100例风湿关节

AIM:强直性脊柱炎(AS)患者增加了心血管和脑血管死亡率

强直性脊柱炎(AS)是一种慢性炎性关节炎,影响年轻成人脊柱。它与过多的心脑血管的发病率有关。该研究的目的是为了确定AS病人是否增加了心脑血管死亡率的风险。该项以人群为基础的回顾性队列研究使用了健康管理的数据。在加拿大安大略省进行。该研究的参与者为21473例15岁及以上AS患者,86606例无AS的参与者作为对照,并对他们的年龄,性别和居住位置进行了匹配。主要成果是心脑血管死亡的复合结果。研究人员

周杰伦的脊柱炎又严重了,这病真的治不好吗?

脊柱炎这个小妖精,竟然还敢折磨我们家杰伦!啥?还要折磨一辈子! 来源KK健康,转载请联系原作者Dr.K (zhongguokepu@163.com)

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