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Clin Gastroenterol Hepatol:抗病毒或降乙肝患者肝癌风险

2014-06-17 伊文 生物谷

   近日,刊登在国际杂志Clinical Gastroenterology and Hepatology上的一篇研究论文中,来自亚特兰大疾病预防控制中心的研究人员通过研究发现,抗病毒疗法或许可以成功抑制乙型肝炎病人发展为肝细胞癌(肝癌的一种形式)。 文章中,研究者对超过2600名运用抗病毒疗法治疗的乙肝病毒患者进行分析研究,进行长达5年的抗病毒疗法后患者患肝细胞

  

近日,刊登在国际杂志Clinical Gastroenterology and Hepatology上的一篇研究论文中,来自亚特兰大疾病预防控制中心的研究人员通过研究发现,抗病毒疗法或许可以成功抑制乙型肝炎病人发展为肝细胞癌(肝癌的一种形式)。

文章中,研究者对超过2600名运用抗病毒疗法治疗的乙肝病毒患者进行分析研究,进行长达5年的抗病毒疗法后患者患肝细胞癌的发生率明显降低了;总的来讲在研究期间有3%的患者发生了肝细胞癌,相比未接受抗病毒疗法的患者来讲,接受抗病毒疗法的病人中60%的个体患肝细胞癌的可能性都较小。

Stuart C. Gordon博士表示,研究结果显示,抗病毒疗法实际上降低乙肝患者患肝癌的风险,在美国肝细胞癌在肝癌患者中占据了较大的比例,在50岁及以上的男性个体中肝细胞癌尤为常见;如果癌症不能得到及时治疗,其通常在3-6个月里是非常危险的。在很多病例中肝细胞癌是由于肝脏结疤(肝硬化)而致,而饮酒、乙肝以及肝脏的慢性炎症是引发肝硬化的主要原因。

最后,研究者Joseph Boscarino表示,这项研究首次揭示了抗病毒疗法和抑制乙肝患者患肝癌之间的关联,基于本文的数据,临床医生们就可以根据患者自身的状况来进行一定的抗病毒疗法来抑制乙肝患者肝癌的发生。

原始出处

Gordon SC1, Lamerato LE2, Rupp LB2, Li J2, Holmberg SD3, Moorman AC3, Spradling PR3, Teshale EH3, Vijayadeva V4, Boscarino JA5, Henkle EM6, Oja-Tebbe N2, Lu M2; CHeCS Investigators.Antiviral therapy for chronic hepatitis B virus infection and development of hepatocellular carcinoma in a US population.Clin Gastroenterol Hepatol. 2014 May;

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    2014-11-18 许安
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2063891, encodeId=feef2063891c4, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Jan 12 16:05:00 CST 2015, time=2015-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710717, encodeId=94171e10717f7, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Oct 24 19:05:00 CST 2014, time=2014-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071537, encodeId=80ab20e1537d3, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Nov 18 10:05:00 CST 2014, time=2014-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671745, encodeId=78e816e1745a0, content=<a href='/topic/show?id=0bcc2342943' target=_blank style='color:#2F92EE;'>#乙肝患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23429, encryptionId=0bcc2342943, topicName=乙肝患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1826842253, createdName=sjzlzc016, createdTime=Sat Sep 06 14:05:00 CST 2014, time=2014-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061435, encodeId=6efd206143564, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Oct 15 18:05:00 CST 2014, time=2014-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292311, encodeId=cf44129231104, content=<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Jun 19 02:05:00 CST 2014, time=2014-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426585, encodeId=bdb1142658516, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Jun 19 02:05:00 CST 2014, time=2014-06-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2063891, encodeId=feef2063891c4, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Jan 12 16:05:00 CST 2015, time=2015-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710717, encodeId=94171e10717f7, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Oct 24 19:05:00 CST 2014, time=2014-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071537, encodeId=80ab20e1537d3, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Nov 18 10:05:00 CST 2014, time=2014-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671745, encodeId=78e816e1745a0, content=<a href='/topic/show?id=0bcc2342943' target=_blank style='color:#2F92EE;'>#乙肝患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23429, encryptionId=0bcc2342943, topicName=乙肝患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1826842253, createdName=sjzlzc016, createdTime=Sat Sep 06 14:05:00 CST 2014, time=2014-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061435, encodeId=6efd206143564, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Oct 15 18:05:00 CST 2014, time=2014-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292311, encodeId=cf44129231104, content=<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Jun 19 02:05:00 CST 2014, time=2014-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426585, encodeId=bdb1142658516, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Jun 19 02:05:00 CST 2014, time=2014-06-19, status=1, ipAttribution=)]
    2014-06-19 yahu
  7. [GetPortalCommentsPageByObjectIdResponse(id=2063891, encodeId=feef2063891c4, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Jan 12 16:05:00 CST 2015, time=2015-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710717, encodeId=94171e10717f7, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Oct 24 19:05:00 CST 2014, time=2014-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071537, encodeId=80ab20e1537d3, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Nov 18 10:05:00 CST 2014, time=2014-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671745, encodeId=78e816e1745a0, content=<a href='/topic/show?id=0bcc2342943' target=_blank style='color:#2F92EE;'>#乙肝患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23429, encryptionId=0bcc2342943, topicName=乙肝患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1826842253, createdName=sjzlzc016, createdTime=Sat Sep 06 14:05:00 CST 2014, time=2014-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061435, encodeId=6efd206143564, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Oct 15 18:05:00 CST 2014, time=2014-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292311, encodeId=cf44129231104, content=<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Jun 19 02:05:00 CST 2014, time=2014-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426585, encodeId=bdb1142658516, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Jun 19 02:05:00 CST 2014, time=2014-06-19, status=1, ipAttribution=)]
    2014-06-19 gwc384
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