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JCEM:COVID-19住院患者维生素D状况分析

2020-10-28 MedSci原创 MedSci原创

与基于人群的对照组相比,住院的COVID-19患者25OHD水平较低,这些患者缺乏症的患病率较高。研究人员没有发现维生素D浓度或维生素缺乏与疾病严重程度之间的任何关联。

维生素D状态在COVID-19患者中的作用尚有争议。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估住院的COVID-19患者血清25-羟基维生素D(25OHD)水平,并分析维生素D状况对疾病严重程度的影响。

这项回顾性病例对照研究纳入了216例COVID-19患者和197例基于人群的对照者。两组受试者均测量了血清25OHD水平。此外,还评估了血清25OHD水平与COVID-19严重程度(入住重症监护病房、需要机械通气或死亡)之间的关系。

在216名患者中,19名患者接受了维生素D补充剂治疗,并分别进行了分析。在COVID-19患者中,25OHD平均±SD水平为13.8±7.2 ng/ml,而对照组为20.9±7.4 ng/ml(p<0.0001)。男性的25OHD值低于女性,在82.2%的COVID-19病例和47.2%的人群对照者中发现维生素D缺乏症(p<0.0001)。25OHD水平与血清铁蛋白(p=0.013)和D-二聚体水平(p=0.027)成反比。维生素D缺乏症的COVID-19患者与25OHD≥20 ng/ml的患者相比,高血压和血管疾病的患病率更高,血清铁蛋白和肌钙蛋白水平升高,住院时间更长。维生素D缺乏症和COVID-19严重程度之间没有因果关系。

与基于人群的对照组相比,住院的COVID-19患者25OHD水平较低,这些患者缺乏症的患病率较高。研究人员没有发现维生素D浓度或维生素缺乏与疾病严重程度之间的任何关联。

原始出处:

José L Hernández.et al.Vitamin D Status in Hospitalized Patients With SARS-CoV-2 Infection.JCEM.2020.https://doi.org/10.1210/clinem/dgaa733

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    2021-07-30 achengzhao
  2. [GetPortalCommentsPageByObjectIdResponse(id=2063377, encodeId=84bb20633e7ea, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Fri Jul 30 23:09:37 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777995, encodeId=daf41e77995fd, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Mon Sep 13 11:09:37 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895081, encodeId=d7068950812e, content=住院的COVID-19患者25OHD水平较低,这些患者缺乏症的患病率较高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Oct 28 14:22:46 CST 2020, time=2020-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895067, encodeId=51fd89506e3e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5naj2gSR9rcV32BeLLgjqbaTr4zP0gVVSlA0oHBTw7uw864qyUiblxVT6cRfQxicFMmPDuLvvEJdOia5dUVniaiavicw/132, createdBy=722a2318727, createdName=谭金亮, createdTime=Wed Oct 28 13:13:22 CST 2020, time=2020-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895062, encodeId=1f3b89506259, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61022504273, createdName=124a6bfdm47暂无昵称, createdTime=Wed Oct 28 13:02:35 CST 2020, time=2020-10-28, status=1, ipAttribution=)]
    2021-09-13 smallant2015
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    2020-10-28 Jessica

    住院的COVID-19患者25OHD水平较低,这些患者缺乏症的患病率较高。

    0

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    2020-10-28 谭金亮

    0

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    2020-10-28 124a6bfdm47暂无昵称

    学习

    0

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