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BMJ:“大脚趾疼痛10年”案例报道

2015-11-06 Mechront 译 MedSci原创

70岁老年女性右大脚趾疼痛10年。近节指骨骨节突出。X线提示皮质增厚,侵入骨髓腔;可见明显粗小梁;近节指骨骨质的扩张。该患者诊断为:(大脚趾)单骨性 Paget's病。讨论:可能的诊断有:Paget's病、骨转移癌、感染性指炎、银屑病性关节病、肢骨纹状肥大。基于临床表现和影像学资料诊断为单骨性 Paget's病。因为缺乏系统性症状,并且该表现长期存在,所以不大可能是感染性指炎、骨转移癌和银屑病性关

70岁老年女性右大脚趾疼痛10年。近节指骨骨节突出。X线提示皮质增厚,侵入骨髓腔;可见明显粗小梁;近节指骨骨质的扩张。


该患者诊断为:(大脚趾)单骨性 Paget's病。

讨论:

可能的诊断有:Paget's病、骨转移癌、感染性指炎、银屑病性关节病、肢骨纹状肥大。

基于临床表现和影像学资料诊断为单骨性 Paget's病。因为缺乏系统性症状,并且该表现长期存在,所以不大可能是感染性指炎、骨转移癌和银屑病性关节病。粗小梁可排除肢骨纹状肥大诊断。

随着年龄增长Paget's病越来越常见,男性多余女性。西方国家该疾病的患病率有明显的地区差异,有报道称20世纪70年代英国患病率最高。

疼痛可能是由于患骨发生微小骨折导致的;因为患骨变性的关节面,会导致相邻关节的骨关节病。

该患者的治疗包括使用鞋垫和非甾体抗炎药(缓解疼痛)。

原始出处:


Lui TH, Tam KF,et al.An unusual case of a painful big toe.BMJ. 2015 Aug 25;351:h4533.

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    2016-01-15 gaoxiaoe
  2. [GetPortalCommentsPageByObjectIdResponse(id=1847742, encodeId=f5fc184e742e9, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Jan 15 05:17:00 CST 2016, time=2016-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42714, encodeId=fd8d42e140f, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sat Nov 07 06:16:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42691, encodeId=07d142691ab, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151022/IMG56284F436A2E92816.jpg, createdBy=30661658215, createdName=糖果鱼塘, createdTime=Fri Nov 06 22:43:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42682, encodeId=c59e4268230, content=不排除痛风吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151101/IMG5635562CC617F7689.jpg, createdBy=bf351605554, createdName=xjbtdbs150wgf, createdTime=Fri Nov 06 20:39:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42672, encodeId=2d35426e2e1, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=246b1661477, createdName=1dded6ffm94(暂无匿称), createdTime=Fri Nov 06 16:07:00 CST 2015, time=2015-11-06, status=1, ipAttribution=)]
    2015-11-07 240612799

    0

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    2015-11-06 糖果鱼塘

    。。。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1847742, encodeId=f5fc184e742e9, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Jan 15 05:17:00 CST 2016, time=2016-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42714, encodeId=fd8d42e140f, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sat Nov 07 06:16:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42691, encodeId=07d142691ab, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151022/IMG56284F436A2E92816.jpg, createdBy=30661658215, createdName=糖果鱼塘, createdTime=Fri Nov 06 22:43:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42682, encodeId=c59e4268230, content=不排除痛风吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151101/IMG5635562CC617F7689.jpg, createdBy=bf351605554, createdName=xjbtdbs150wgf, createdTime=Fri Nov 06 20:39:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42672, encodeId=2d35426e2e1, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=246b1661477, createdName=1dded6ffm94(暂无匿称), createdTime=Fri Nov 06 16:07:00 CST 2015, time=2015-11-06, status=1, ipAttribution=)]
    2015-11-06 xjbtdbs150wgf

    不排除痛风吗?

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1847742, encodeId=f5fc184e742e9, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Jan 15 05:17:00 CST 2016, time=2016-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42714, encodeId=fd8d42e140f, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sat Nov 07 06:16:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42691, encodeId=07d142691ab, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151022/IMG56284F436A2E92816.jpg, createdBy=30661658215, createdName=糖果鱼塘, createdTime=Fri Nov 06 22:43:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42682, encodeId=c59e4268230, content=不排除痛风吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151101/IMG5635562CC617F7689.jpg, createdBy=bf351605554, createdName=xjbtdbs150wgf, createdTime=Fri Nov 06 20:39:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42672, encodeId=2d35426e2e1, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=246b1661477, createdName=1dded6ffm94(暂无匿称), createdTime=Fri Nov 06 16:07:00 CST 2015, time=2015-11-06, status=1, ipAttribution=)]
    2015-11-06 1dded6ffm94(暂无匿称)

    长知识

    0

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