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CEBP:睡眠问题或增加前列腺癌风险

2013-05-09 koo 生物360

睡眠不好会让人精神不振,注意力无法集中,但睡眠不好的影响远不止这些。一项最新研究显示,睡眠不好或许还会增加男性罹患前列腺癌的风险。近日,冰岛大学研究人员在美国《癌症流行病学、生物标志和预防》(Cancer Epidemiology, Biomarkers & Prevention)期刊上报告说,睡眠问题损害健康已成为现代社会的普遍问题。比如,此前有研究发现,睡眠不好的女性罹患乳腺癌的风险高

睡眠不好会让人精神不振,注意力无法集中,但睡眠不好的影响远不止这些。一项最新研究显示,睡眠不好或许还会增加男性罹患前列腺癌的风险。
近日,冰岛大学研究人员在美国《癌症流行病学、生物标志和预防》(Cancer Epidemiology, Biomarkers & Prevention)期刊上报告说,睡眠问题损害健康已成为现代社会的普遍问题。比如,此前有研究发现,睡眠不好的女性罹患乳腺癌的风险高。但科学家并不清楚睡眠问题与男性前列腺癌之间的关联。
在这项新研究中,研究人员以2100多名67岁至96岁的冰岛男性为对象,研究睡眠对前列腺癌风险的影响。他们首先调查了这些研究对象的睡眠质量,发现其中14.4%的人存在严重或非常严重的睡眠问题,包括难以入睡、夜间易醒、晨醒过早等。这些人参与研究时均未患前列腺癌,但跟踪研究5年后,其中6.4%罹患前列腺癌。
在考虑了年龄等影响因素后,研究人员发现,睡眠不好的人罹患前列腺癌的风险,是没有睡眠问题者的1.6倍到2.1倍。研究人员表示,如果这一结果得到进一步研究的验证,那么要降低罹患前列腺癌的风险,睡眠也许是一个潜在的干预目标。

Background: 
Although positive associations have consistently been reported between sleep disruption and breast cancer, less is known about its potential role in prostate cancer.
Methods: 
Within the prospective AGES-Reykjavik cohort study, we followed 2,102 men recruited in 2002–2006 until the end of 2009. Participants answered questions on sleep disruption. Information on the occurrence of prostate cancer was obtained through record linkages across the Icelandic Cancer Registry. We used Cox regression models with 95% confidence intervals (CI) to estimate HRs of prostate cancer by symptoms of sleep disruption.
Results: 
During follow-up, 135 men (6.4%) were diagnosed with prostate cancer. Compared with men without sleep disruption, those with problems falling and staying asleep were at significantly increased risk of prostate cancer [HR, 1.7 (95% CI, 1.0–2.9) and 2.1 (95% CI, 1.2–3.7)], respectively, with increasing sleep disruption severity. When restricted to advanced prostate cancer (≥ stage T3 or lethal disease), these associations became even stronger [HR 2.1 (95% CI, 0.7–6.2) and 3.2 (95% CI, 1.1–9.7)]. The results did not change after excluding from the analyses men who woke up during the night, indicative of nocturia, suggesting limited risk of reverse association.
Conclusions: 
Our data suggest that certain aspects of sleep disruption may confer an increased risk of prostate cancer and call for additional, larger studies with longer follow-up times.

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