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JACC:MA-CABG是多支冠状动脉疾病的更佳治疗方法

2015-09-22 崔倩 译 MedSci原创

与使用任何裸金属支架(BMS)或药物洗脱支架(DES)进行经皮冠状动脉介入治疗(PCI)相比,传统的单一动脉冠状动脉旁路移植(SA-CABG)治疗多支冠状动脉病变已显示出中期生存和再干预的优势。本研究旨在探讨包括动脉期多时冠状动脉旁路移植术(MA-CABG)的潜在增加的优势长期的结果。该研究包括8402单一部位,主要是血运重建,多支冠状动脉疾病的患者:2207例接受BMS-PCI治疗(年龄66.6

与使用任何裸金属支架(BMS)或药物洗脱支架(DES)进行经皮冠状动脉介入治疗(PCI)相比,传统的单一动脉冠状动脉旁路移植(SA-CABG)治疗多支冠状动脉病变已显示出中期生存和再干预的优势。

本研究旨在探讨包括动脉期多时冠状动脉旁路移植术(MA-CABG)的潜在增加的优势长期的结果。

该研究包括8402单一部位,主要是血运重建、多支冠状动脉疾病的患者:2207例接受BMS-PCI治疗(年龄66.6±11.9岁);2381例接受DES-PCI治疗(年龄65.9±11.7岁);2289例接受SA-CABG治疗(年龄69.3±9.0岁);1525例接受MA-CABG治疗(年龄58.3±8.7岁)。患者24小时内心肌梗死,休克,或左主支架被排除在外。研究人员使用Kaplan-Meier分析和Cox回归来分析9年的全因死亡率和计划外再次接受BMS-PCI和DES-PCI干预,并与倾向匹配的SA-CABG和MA-CABG队列进行了比较。

BMS-PCI比SA-CABG导致较差的生存率,特别是从0至7年时(P=0.015),与MA-CABG相比在很大程度上导致较差的生存率(9年的随访:76.3% vs 86.9%;P<0.001)。手术与BMS-PCI的危险比(HR)为:vs SA-CABG,HR:0.87;vs MA-CABG,HR:0.38。除了适度的0至3年手术优势,DES-PCI表现出与SA-CABG类似的生存率(HR:1.06;P=0.615)。与MA-CABG相比,DES-PCI在5年(86.3% vs 95.6%)和9年(82.8% vs 89.8%)时表现出更糟糕的生存率(HR:0.45;P<0.001)。对于所有的比较使用PCI再次介入治疗明显效果较差(所有P<0.001)。

与BMS-PCI或DES-PCI相比,动脉期多时外科血管成形术,都大大增加了死亡率和无需再次介入的生存率。因此,MA-CABG代表了多支冠状动脉疾病的最佳治疗方法,多学科心脏团队要积极采用该方法作为最好的循证治疗。

原始出处:

Robert H. Habib,Kamellia R. Dimitrova, Sanaa A. Badour,et al.CABG Versus PCI:Greater Benefit in Long-Term Outcomes With Multiple Arterial Bypass Grafting,JACC,2015.9.22

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    2016-08-16 hbwxf
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1853413, encodeId=14a41853413ef, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Aug 16 02:48:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252864, encodeId=aa7b1252864a5, content=<a href='/topic/show?id=463230886b8' target=_blank style='color:#2F92EE;'>#冠状动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30886, encryptionId=463230886b8, topicName=冠状动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Sep 24 04:48:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325106, encodeId=9247132510637, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Sep 24 04:48:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399186, encodeId=08d31399186be, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Thu Sep 24 04:48:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37197, encodeId=f0de3e1971f, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:06:00 CST 2015, time=2015-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37198, encodeId=69963e1980e, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:06:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2015-09-23 x35042875

    解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。

    0

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    2015-09-23 x35042875

    解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。

    0

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