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Epidemiology:尿双酚A或增高国人甲亢风险

2013-01-29 Epidemiology dxy 葛根

双酚A甲亢甲状腺功能亢进
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　　动物实验发现双酚A可与甲状腺激素受体结合从而影响甲状腺功能，但这种关联性研究尚未在人群中展开。为了探讨中国人群中尿双酚A与甲状腺功能的关系，我国上海交通大学医学院附属瑞金医院宁光教授开展了一项横断面研究。研究发现，高水平的尿双酚A与甲状腺功能亢进相关。研究于2013年1月18日在线发表于《流行病学》（Epidemiology）杂志。 　　该研究在上海市宝山区淞南社区招募志愿者，从2009年1

　　动物实验发现双酚A可与甲状腺激素受体结合从而影响甲状腺功能，但这种关联性研究尚未在人群中展开。为了探讨中国人群中尿双酚A与甲状腺功能的关系，我国上海交通大学医学院附属瑞金医院宁光教授开展了一项横断面研究。研究发现，高水平的尿双酚A与甲状腺功能亢进相关。研究于2013年1月18日在线发表于《流行病学》（Epidemiology）杂志。

　　该研究在上海市宝山区淞南社区招募志愿者，从2009年1月至2009年8月募集该地区40及40岁以上志愿者3394名。使用多元线性回归分析尿双酚A与甲状腺功能的关系。志愿者依据甲状腺功能状态进一步分类，应用logistic回归确认尿双酚A与甲状腺功能的关系。

　　结果发现，在男性中，尿双酚A每增加一个四分位数，FT3增加0.068 pmol/l（95%CI：0.065–0.071），TSH降低0.084 uIU/ml(–0.099––0.069）；而在女性中，FT3增加0.10 pmol/l（0.09–0.11）,TSH降低0.13 uIU/ml(–0.14––0.11）。高水平的尿双酚A与甲状腺功能亢进相关（aOR=1.71(1.26–2.32)。

　　该研究得出的结论与以往的动物模型和流行病学研究报道双酚A暴露与甲状腺功能异常有关相一致。但由于该研究属于横断面研究，通过该研究尚不能确定两者之间的因果关系。


Urinary Bisphenol A Concentration and Thyroid Function in Chinese Adults
Background
Bisphenol A (BPA) is an endocrine disruptor that in animal studies can bind to the thyroid hormone receptor and affect thyroid function. Relevant epidemiologic studies are limited and results are inconsistent. We explored the relationship between urinary BPA and thyroid function in a Chinese population.
Methods
The study population included 3394 subjects age 40 years or older who were enrolled in a population-based study from Songnan Community, Baoshan District, Shanghai, China, from June through August 2009. We analyzed the association between urinary BPA and thyroid function using multivariate linear regression. Participants were further divided according to thyroid function status, and logistic regression was applied to determine the relationship between urinary BPA and thyroid function.
Results
Each one-quartile increase in BPA was related to an increase of 0.068 pmol/l (95% confidence interval = 0.065- 0.071) in free triiodothyronine and a 0.084 [mu]IU/ml decline (-0.099 to -0.069) in thyroid-stimulating hormone (TSH) in men. For women, there was a 0.10 pmol/l (0.09 to 0.11) increase in free triiodothyronine and a 0.13 [mu]IU/ml decline (-0.14 to -0.11) in TSH. High urinary BPA level was associated with increased thyroid function (adjusted odds ratio = 1.71 [1.26 to 2.32]).
Conclusions
Our results support previous reports of associations between BPA exposure and altered thyroid hormones in animal models and epidemiologic studies. Because our study is cross-sectional, no causal relationships can be established.
    

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    2013-02-25 chenhongpeng

    #epidemiology#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1898677, encodeId=a56b18986e708, content=<a href='/topic/show?id=1fa568e6ec' target=_blank style='color:#2F92EE;'>#epidemiology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6876, encryptionId=1fa568e6ec, topicName=epidemiology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Mon Feb 25 20:44:00 CST 2013, time=2013-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350089, encodeId=be6a135008970, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jan 31 02:44:00 CST 2013, time=2013-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561542, encodeId=c50415615424f, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Jan 31 02:44:00 CST 2013, time=2013-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567551, encodeId=9017156e5511a, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Jan 31 02:44:00 CST 2013, time=2013-01-31, status=1, ipAttribution=)]
    2013-01-31 zhaojie88

    #双酚A#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1898677, encodeId=a56b18986e708, content=<a href='/topic/show?id=1fa568e6ec' target=_blank style='color:#2F92EE;'>#epidemiology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6876, encryptionId=1fa568e6ec, topicName=epidemiology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Mon Feb 25 20:44:00 CST 2013, time=2013-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350089, encodeId=be6a135008970, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jan 31 02:44:00 CST 2013, time=2013-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561542, encodeId=c50415615424f, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Jan 31 02:44:00 CST 2013, time=2013-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567551, encodeId=9017156e5511a, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Jan 31 02:44:00 CST 2013, time=2013-01-31, status=1, ipAttribution=)]
    2013-01-31 liuxiaona

    #增高#

    0

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    2013-01-31 liuxiaona

    #增高#

    0

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