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Gastroenterology:多发性锯齿状息肉患者及其一级亲属患结直肠癌的风险增加!

2017-04-10 xing.T MedSci原创

由此可见,多发性锯齿状息肉但不符合锯齿状息肉病诊断的患者及其一级亲属CRC的风险与确诊为锯齿状息肉病的患者相似。

近日,消化病领域权威杂志Gastroenterology上发表了一篇研究文章,研究人员旨在调查有多个锯齿状息肉但不符合世界卫生组织锯齿状息肉病综合征诊断标准的患者及其亲属是否有类似的结直肠癌(CRC)风险,当他们诊断为锯齿状息肉病时。

研究人员收集了有10多个结肠息肉的患者数据,这些患者是从西班牙的24家医院于2008年至2009年期间招募的,旨在研究多发结肠息肉的原因。研究人员分析了53例符合锯齿状息肉病纳入标准的患者和145例不符合这些标准但其整个结肠有超过10个息肉的患者,其中超过50%为锯齿状。研究人员计算了两组患者以及他们一级亲属经年龄和性别调整后的CRC标准化发病率(SIR)。

研究人员发现在确诊的锯齿状息肉病患者和多个锯齿状息肉患者之间CRC的患病率相似(比值比为1.35;95%可信区间为0.64-2.82;P=0.40)。对于锯齿状息肉病患者CRC的SIR(0.51;95%可信区间为0.01-2.82)与多锯齿状息肉患者CRC的SIR(0.74;95%可信区间为0.20-1.90,P=0.70)没有显著差异。这两个组的一级亲属CRC的SIR(锯齿状息肉病:3.28,95%可信区间为2.16-4.77;多锯齿状息肉:2.79,95%可信区间为2.10-3.63;P=0.50)也无显著差异。Kaplan-Meier分析显示在随访期间CRC的发病率在两组之间无显著差异(log=0.6)。

由此可见,多发性锯齿状息肉但不符合锯齿状息肉病诊断的患者及其一级亲属CRC的风险与确诊为锯齿状息肉病的患者相似。

原始出处:


Cecilia Egoavil, et al. Increased Risk of Colorectal Cancer in Patients With Multiple Serrated Polyps and Their First-degree Relatives.Gastroenterology,2017.http://www.gastrojournal.org/article/S0016-5085(17)35413-6/fulltext

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    2017-07-17 jml2009
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encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Dec 10 23:48:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711000, encodeId=3a5f1e11000ae, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Sep 16 21:48:00 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188315, encodeId=f55618831538, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Mon Apr 17 22:37:07 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186991, encodeId=371918699111, content=多发性息肉,琚齿状息肉病。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Apr 13 06:08:49 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452888, encodeId=f2df14528880b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504267, encodeId=faf3150426eaa, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585521, encodeId=c4001585521e2, content=<a href='/topic/show?id=2320193980a' target=_blank style='color:#2F92EE;'>#一级亲属#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19398, encryptionId=2320193980a, topicName=一级亲属)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d17222039, createdName=hukaixun, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=)]
    2017-12-10 许安
  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Mon Apr 17 22:37:07 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186991, encodeId=371918699111, content=多发性息肉,琚齿状息肉病。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Apr 13 06:08:49 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452888, encodeId=f2df14528880b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, 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href='/topic/show?id=2320193980a' target=_blank style='color:#2F92EE;'>#一级亲属#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19398, encryptionId=2320193980a, topicName=一级亲属)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d17222039, createdName=hukaixun, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2064063, encodeId=fb782064063e7, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Apr 13 04:48:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079192, encodeId=310120e919284, content=<a href='/topic/show?id=d2726808307' target=_blank style='color:#2F92EE;'>#状息肉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68083, encryptionId=d2726808307, topicName=状息肉)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Mon Apr 17 22:37:07 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186991, encodeId=371918699111, content=多发性息肉,琚齿状息肉病。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Apr 13 06:08:49 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452888, encodeId=f2df14528880b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504267, encodeId=faf3150426eaa, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585521, encodeId=c4001585521e2, content=<a href='/topic/show?id=2320193980a' target=_blank style='color:#2F92EE;'>#一级亲属#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19398, encryptionId=2320193980a, topicName=一级亲属)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d17222039, createdName=hukaixun, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=)]
    2017-04-17 绛珠草小姐

    学习了,谢谢

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Mon Apr 17 22:37:07 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186991, encodeId=371918699111, content=多发性息肉,琚齿状息肉病。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Apr 13 06:08:49 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452888, encodeId=f2df14528880b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504267, encodeId=faf3150426eaa, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585521, encodeId=c4001585521e2, content=<a href='/topic/show?id=2320193980a' target=_blank style='color:#2F92EE;'>#一级亲属#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19398, encryptionId=2320193980a, topicName=一级亲属)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d17222039, createdName=hukaixun, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=)]
    2017-04-13 1e0f8808m18(暂无匿称)

    多发性息肉,琚齿状息肉病。学习了。

    0

  8. 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href='/topic/show?id=2320193980a' target=_blank style='color:#2F92EE;'>#一级亲属#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19398, encryptionId=2320193980a, topicName=一级亲属)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d17222039, createdName=hukaixun, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2064063, encodeId=fb782064063e7, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Apr 13 04:48:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079192, encodeId=310120e919284, content=<a href='/topic/show?id=d2726808307' target=_blank style='color:#2F92EE;'>#状息肉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68083, encryptionId=d2726808307, topicName=状息肉)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Mon Apr 17 22:37:07 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186991, encodeId=371918699111, content=多发性息肉,琚齿状息肉病。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Apr 13 06:08:49 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452888, encodeId=f2df14528880b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, 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href='/topic/show?id=2320193980a' target=_blank style='color:#2F92EE;'>#一级亲属#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19398, encryptionId=2320193980a, topicName=一级亲属)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d17222039, createdName=hukaixun, createdTime=Wed Apr 12 14:48:00 CST 2017, time=2017-04-12, status=1, ipAttribution=)]
  10. [GetPortalCommentsPageByObjectIdResponse(id=2064063, encodeId=fb782064063e7, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Apr 13 04:48:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079192, encodeId=310120e919284, content=<a href='/topic/show?id=d2726808307' target=_blank style='color:#2F92EE;'>#状息肉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68083, encryptionId=d2726808307, topicName=状息肉)], attachment=null, authenticateStatus=null, createdAvatar=, 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