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JCI Insight:“神奇”蛋白质使癌细胞失去控制能力,束手就擒

2017-05-14 Heather_z727 来宝网

在人体内,抗癌免疫力被癌症大军暗中控制着,这也是癌症难以攻克的原因,但是如今一项最新的研究显示,科学家找到了人体内自然的防盗控制系统,一场癌细胞对战自身免疫力的大战即将拉开序幕。

在人体内,抗癌免疫力被癌症大军暗中控制着,这也是癌症难以攻克的原因,但是如今一项最新的研究显示,科学家找到了人体内自然的防盗控制系统,一场癌细胞对战自身免疫力的大战即将拉开序幕。

来自美国密歇根大学的研究人员发现一种蛋白质,这种蛋白质可以使癌细胞无力控制免疫系统,使其束手就擒。研究人员表示,这种名为自由C3d的蛋白质有望成为癌症疫苗的方向的指导方向,以及最新的抗癌方法。

“我们此次抗癌方法的原理在于摧毁癌细胞控制免疫系统的能力,尽管免疫疗法在对抗癌症的过程中初现成果,但是缺点就在于免疫疗法并不具体,而且药物到处横行,带来严重的副作用。然而,我们此次疗法却会寻找全新的给药路径,这种方法更加优越,在我们的试验中,我们将自由C3d直接注入癌细胞当中,目前没有出现任何副作用。”

C3d是补体系统的一个正常部分,它与人体的免疫系统相关,通过抗体激活之后,补体系统也会像免疫系统一样对抗外来侵害。有很多C3d是与外部细胞相联系的,但是也有一些是自由身,之前,人们认为这些自由的C3d没有任何功能,然而,在此次试验中,研究人员发现C3d作为癌症疫苗的潜能,以及作为全新抗癌方法的希望。希望C3d的加入可以为抗癌大战助一臂之力。

原始出处:

Jeffrey L. Platt, et al. C3d regulates immune checkpoint blockade and enhances antitumor immunity. JCI Insight. 2017;2(9):e90201. doi:10.1172/jci.insight.90201. First published May 4, 2017

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    2017-05-19 卡圣

    学习了,谢谢

    0

  4. 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  5. 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level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon May 15 10:40:02 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198307, encodeId=c76019830ee9, content=学习并分享!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon May 15 09:37:26 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198293, encodeId=0a89198293c1, content=谢谢,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon May 15 09:02:17 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
    2017-05-16 yxch36
  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon May 15 09:02:17 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
    2017-05-15 卡圣

    学习了,谢谢

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon May 15 09:02:17 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
    2017-05-15 139****5926

    好文章学习了

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon May 15 09:02:17 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
    2017-05-15 luominglian113

    补体系统激活,抗癌新方法,谢谢分享

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon May 15 09:02:17 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
    2017-05-15 大爰

    学习并分享!!!

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon May 15 09:02:17 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
    2017-05-15 执着追梦

    谢谢,感谢分享

    0

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近年来,随着超声分子影像技术的发展以及在临床中的应用,科学家们已经能够利用超声分子技术为患者提更加精准的诊疗了。如今超声医学已经突破了传统超声显像诊断领域的限制,迈入了“纳米”时代。而且研究人员也开发出了更加新型的超声技术,能够敏感地发现实质性脏器内常规影像检查无法发现的转移性癌症病灶,并在超声波的介导下,传递和释放靶向抗癌药物,精准地杀死癌细胞。 那么近年来科学家们利用超声技术在诊

Nature:免疫疗法与T细胞联手,找到癌细胞“老窝”,将其连根拔起

一项新的研究指出,免疫疗法结合T细胞为癌症患者带来希望,而且在治疗血癌方面已经取得了一些实际进展和成功,目前正在着手应对实体肿瘤,T细胞产生的信号分子干扰素γ在此疗法中起到了至关重要的作用,它切断了肿瘤的供血来源。 免疫系统使人体对付病毒和疾病最英勇善战的团队,所以使用免疫系统来对抗癌症怎么样呢?长久以来,科学家们一直在努力利用免疫系统中的T细胞来达到对抗癌症的作用,它们是特殊的移动部队

NAT CHEM:转运氯离子,小分子抗癌新战术?

细胞自噬(autophagy)顾名思义就是指细胞自我吞噬,尤其是当细胞在营养不良或是受到外界伤害时,细胞的这种行为可以帮助其度过困难时期。发现这一现象背后机理的日本科学家大隅良典也在去年收获了诺贝尔生理学或医学奖。细胞凋亡(apoptosis)是细胞程序性的主动死亡,在复杂的调控下可以去除机体不需要或异常的细胞,对生物体的进化、内环境的稳定以及系统发育意义重大。在细胞过度增殖的肿瘤中,细胞自噬的水

新型成像技术或将不断推进癌症深入研究

随着癌症筛查工具的不断涌现,新型的癌症成像技术也给科学家们在癌症诊断及判断患者对药物的反应等相关领域带来了极大帮助,当然这对于改善癌症患者未来的治疗或许意义深远。基于强大的癌症成像技术,研究人员就能够更加快速地发现患者机体中的癌症;同时也能够对癌细胞的一举一动进行实时监测,当然有些成像技术也能够帮助研究者预测患者对癌症药物应答。 那么近年来,新型癌症成像技术到底是如何促进科学家们在癌

ASC:新型药物杀灭癌细胞无毒更有效

普渡大学开发的药物化合物可有效靶向和抑制多种类型癌症的蛋白激酶酶和次级突变型。与常规药物相比,这些化合物是无毒的,可能消除不利的患者副作用。 普渡大学化学系教授和创新开发人员Hermin Sintim说:“蛋白激酶是参与细胞信号传导的一类重要蛋白质,它们调节细胞生长,死亡(细胞凋亡)和迁移等多种过程,人类细胞中有大约600种不同的蛋白激酶。由于参与细胞信号传导,蛋白激酶也参与癌症的形成。

Nature:新型血检,早一年发现癌细胞,把癌症扼杀在摇篮里

当癌细胞还是一个小小的微细胞,X射线和CT都看不出来的时候,英国的科学家们就可以通过血检将其捕获。这一发现对医生和患者来说都是好消息,为治疗争取了致命的时间,此次研究的目标是肺癌,然而由于研究科目非常基础,因此也适用于所有类型的癌症。  在此次研究中,英国癌症研究所的研究人员取得了肺癌患者肿瘤切除过程中的血液样本,他们分析了缺陷DNA,并为每一个患者制作了癌症基因指纹,在手术后

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