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Adv Rheumatol:研究揭示高安氏动脉炎患者内皮祖细胞和血管内皮生长因子的水平

2019-06-26 不详 网络

内皮祖细胞(EPC)负责内皮损伤修复。Takayasu的动脉炎(TA)是一种影响大血管的慢性炎症性疾病。该研究旨在评估EPC患者的数量和血管内皮生长因子(VEGF)的水平以及这些变量在TA患者中的关系。研究共纳入包括30名TA患者和30名健康对照者。通过流式细胞术和细胞培养评估EPC,并通过商业ELISA试剂盒进行VEGF定量。结果显示,患者和对照组的年龄相似。患者和对照组的EPC数量(中位数(四

内皮祖细胞(EPC)负责内皮损伤修复。Takayasu的动脉炎(TA)是一种影响大血管的慢性炎症性疾病。该研究旨在评估EPC患者的数量和血管内皮生长因子(VEGF)的水平以及这些变量在TA患者中的关系。

研究共纳入包括30名TA患者和30名健康对照者。通过流式细胞术和细胞培养评估EPC,并通过商业ELISA试剂盒进行VEGF定量。

结果显示,患者和对照组的年龄相似。患者和对照组的EPC数量(中位数(四分位数间距)为0.0073%(0.0081%)vs. 0.0062%(0.0089%),流式细胞仪检测为p = 0.779,27.0(42.3)菌落形成单位(CFU)为27.0 (20.5)CFU,细胞培养p = 0.473,患者和对照组VEGF水平为274.5(395.5)pg/ml,相对于243.5(255.3)pg/ml,p = 0.460。患有活动性和非活动性疾病的患者之间的EPC和VEGF水平。服用抗TNFs的患者中成血管细胞样EPC的数量趋于更高;而使用甲氨蝶呤的患者则更低。

总之,该研究结果表明,与对照相比,TA患者中EPC和VEGF水平的定量没有显著差异,并且在患有活动性和非活动性疾病的患者之间没有观察到差异。

原始出处:

Machado LSG, Oliveira ACD, et al., Endothelial progenitor cells and vascular endothelial growth factor in patients with Takayasu's arteritis. Adv Rheumatol. 2018 Aug 9;58(1):24. doi: 10.1186/s42358-018-0025-9.

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