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Appl Immunohistochem Mol Morphol：免疫组化技术在前列腺病灶活检应用中的评估

2019-01-19 AlexYang MedSci原创

前列腺免疫组化评估
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免疫组化（IHC）在前列腺病灶评估中的使用还没有常规化，且其价值还没有评估。最近，有研究人员提取了2011年到2017年的病理组织切片报告，并对其进行了回顾和分析。研究共包括了4477个活检样本。这些样本通过病理严重程度分类（染色百分比），群体包括1184名良性案例（42%）；168个前列腺上皮内瘤案例（68%）；323个疑似案例（93%）；一级癌症（WHO1）：900 (78%)； 二级癌症(W

免疫组化（IHC）在前列腺病灶评估中的使用还没有常规化，且其价值还没有评估。最近，有研究人员提取了2011年到2017年的病理组织切片报告，并对其进行了回顾和分析。

研究共包括了4477个活检样本。这些样本通过病理严重程度分类（染色百分比），群体包括1184名良性案例（42%）；168个前列腺上皮内瘤案例（68%）；323个疑似案例（93%）；一级癌症（WHO1）：900 (78%)； 二级癌症(WHO2)： 840 (60%)；WHO3癌症： 451 (54%)；WHO4 癌症： 363 (46%)；WHO5癌症： 215 (56%)；癌症等级不能精确确定： 33 (52%)。其中，2个医院分别包括2716个活检案例和1761个活检案例，分别包括了10183和14852个IHC。具有IHC的案例在过去4年时间里减少（在两个医院分别为57%到45%和79%到73%）。35名病理学家解读了大于20个案例，并且一起解释了4418个案例（范围21-415，均值为88）。在4418个案例中，总共进行了2476个IHCs（5.6个/案例）。对35名病理学家来说，每个案例的IHCs平均值/中值/SD/最大值/最小值分别为5.6/4.1/3.9/15.2/0.9。高IHC使用者比低IHC使用者具有更高的恶性肿瘤的可能，但是并不明显。

最后，研究人员指出，IHC在良性和恶性肿瘤中最经常使用，并且依赖于病理学家和医院。然而，上述情况与WHO1癌症发生率无关。另外，诊断频率信息能够帮助确定合理的IHC使用。

原始出处：

Bonert M， El-Shinnawy I， Rahman M et al. Immunohistochemistry Use by Diagnostic Category and Pathologist in 4477 Prostate Core Biopsy Sets Assessed at Two Hospitals. Appl Immunohistochem Mol Morphol. 8 Jan 2019.

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    2019-08-22 yuanming17

    #HIS#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1703640, encodeId=37af1e036402a, content=<a href='/topic/show?id=9b00886536' target=_blank style='color:#2F92EE;'>#HIS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8865, encryptionId=9b00886536, topicName=HIS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133330532258, createdName=yuanming17, createdTime=Thu Aug 22 01:18:00 CST 2019, time=2019-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278120, encodeId=5b6612e8120ae, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Jan 21 05:18:00 CST 2019, time=2019-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438907, encodeId=0339143890e92, content=<a href='/topic/show?id=eb522911994' target=_blank style='color:#2F92EE;'>#免疫组化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29119, encryptionId=eb522911994, topicName=免疫组化)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 21 05:18:00 CST 2019, time=2019-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358677, encodeId=fd593586e7b9, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jan 20 06:42:50 CST 2019, time=2019-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358648, encodeId=c5f135864805, content=学习学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2019/01/02/f667a67c6692f1e356c51a346d5b382f.jpg, createdBy=7b7a2515105, createdName=Janeinair, createdTime=Sat Jan 19 17:07:31 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358640, encodeId=28153586404f, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Jan 19 14:29:06 CST 2019, time=2019-01-19, status=1, ipAttribution=)]
    2019-01-21 仁心济世

    #活检#

    0

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    2019-01-21 zhouqu_8

    #免疫组化#

    0

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    2019-01-20 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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    2019-01-19 Janeinair

    学习学习了

    0

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    2019-01-19 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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