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BJC：身高越高，非黑素瘤皮肤癌风险越高！

2016-11-21 MedSci MedSci原创

非黑素瘤皮肤癌身高SNP
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成人身高已与一些特定部位的癌症风险有关，包括黑色素瘤。但是身高与非黑素瘤皮肤癌(NMSC)之间的联系研究较少。 我们前瞻性地研究了成人身高与鳞状细胞癌(SCC)和基底细胞癌(BCC)风险之间的联系，研究对象为护士健康研究(NHS, n=117 863)和卫生专业人员随访研究(HPFS, n=51 111)中的参与者。 我们还研究了身高相关遗传标记与BCC和SCC风险间的联系，其中389

成人身高已与一些特定部位的癌症风险有关，包括黑色素瘤。

但是身高与非黑素瘤皮肤癌(NMSC)之间的联系研究较少。

我们前瞻性地研究了成人身高与鳞状细胞癌(SCC)和基底细胞癌(BCC)风险之间的联系，研究对象为护士健康研究(NHS, n=117 863)和卫生专业人员随访研究(HPFS, n=51 111)中的参与者。

我们还研究了身高相关遗传标记与BCC和SCC风险间的联系，其中3898例BCC患者，8530例BCC对照者，527例SCC患者，8962例SCC8962 SCC。

控制潜在的混杂因素后，身高每增加10cm，SCC和BCC的HR值分别为1.09 (95% CI: 1.02, 1.15)和1.10 (95% CI: 1.07, 1.13)。687个身高相关遗传标记与BCC和SCC风险无关。

来自两个大型队列研究的数据表明，身高越高，NMSC风险越高。

原始出处：

Xin Li1, Liming Liang1,et al.Height, height-related SNPs, and risk of non-melanoma skin cancer.British Journal of Cancer advance online publication 15 November 2016

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    2016-12-09 sunyl07

    #皮肤癌风险#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1981017, encodeId=0483198101eb4, content=<a href='/topic/show?id=3e3fe2073e5' target=_blank style='color:#2F92EE;'>#皮肤癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72073, encryptionId=3e3fe2073e5, topicName=皮肤癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Fri Dec 09 20:38:00 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061587, encodeId=741d206158e97, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun May 07 23:38:00 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034449, encodeId=256920344496e, content=<a href='/topic/show?id=d17499e79c8' target=_blank style='color:#2F92EE;'>#非黑素瘤皮肤癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99779, encryptionId=d17499e79c8, topicName=非黑素瘤皮肤癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Feb 09 07:38:00 CST 2017, time=2017-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172008, encodeId=3d2a1e200851, content=还有这种关系，开眼界了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Sun Jan 22 16:43:35 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160471, encodeId=6d0d1604e16e, content=谢谢分享，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Dec 05 19:16:56 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479411, encodeId=de6914e9411ec, content=<a href='/topic/show?id=4a571033209b' target=_blank style='color:#2F92EE;'>#黑素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103320, encryptionId=4a571033209b, topicName=黑素瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d4d7523220, createdName=yuhaisheng_ibp_32061713, createdTime=Wed Nov 23 01:38:00 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157259, encodeId=4f3315e2596e, content=这也可以！, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Mon Nov 21 11:04:48 CST 2016, time=2016-11-21, status=1, ipAttribution=)]
    2017-05-07 sjq027

    #癌风险#

    0

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    2017-02-09 yahu

    #非黑素瘤皮肤癌#

    0

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    2017-01-22 wmu姿

    还有这种关系，开眼界了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1981017, encodeId=0483198101eb4, content=<a href='/topic/show?id=3e3fe2073e5' target=_blank style='color:#2F92EE;'>#皮肤癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72073, encryptionId=3e3fe2073e5, topicName=皮肤癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Fri Dec 09 20:38:00 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061587, encodeId=741d206158e97, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun May 07 23:38:00 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034449, encodeId=256920344496e, content=<a href='/topic/show?id=d17499e79c8' target=_blank style='color:#2F92EE;'>#非黑素瘤皮肤癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99779, encryptionId=d17499e79c8, topicName=非黑素瘤皮肤癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Feb 09 07:38:00 CST 2017, time=2017-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172008, encodeId=3d2a1e200851, content=还有这种关系，开眼界了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Sun Jan 22 16:43:35 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160471, encodeId=6d0d1604e16e, content=谢谢分享，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Dec 05 19:16:56 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479411, encodeId=de6914e9411ec, content=<a href='/topic/show?id=4a571033209b' target=_blank style='color:#2F92EE;'>#黑素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103320, encryptionId=4a571033209b, topicName=黑素瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d4d7523220, createdName=yuhaisheng_ibp_32061713, createdTime=Wed Nov 23 01:38:00 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157259, encodeId=4f3315e2596e, content=这也可以！, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Mon Nov 21 11:04:48 CST 2016, time=2016-11-21, status=1, ipAttribution=)]
    2016-12-05 laoli

    谢谢分享，学习了！

    0

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    2016-11-23 yuhaisheng_ibp_32061713

    #黑素瘤#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1981017, encodeId=0483198101eb4, content=<a href='/topic/show?id=3e3fe2073e5' target=_blank style='color:#2F92EE;'>#皮肤癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72073, encryptionId=3e3fe2073e5, topicName=皮肤癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Fri Dec 09 20:38:00 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061587, encodeId=741d206158e97, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun May 07 23:38:00 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034449, encodeId=256920344496e, content=<a href='/topic/show?id=d17499e79c8' target=_blank style='color:#2F92EE;'>#非黑素瘤皮肤癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99779, encryptionId=d17499e79c8, topicName=非黑素瘤皮肤癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Feb 09 07:38:00 CST 2017, time=2017-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172008, encodeId=3d2a1e200851, content=还有这种关系，开眼界了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Sun Jan 22 16:43:35 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160471, encodeId=6d0d1604e16e, content=谢谢分享，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Dec 05 19:16:56 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479411, encodeId=de6914e9411ec, content=<a href='/topic/show?id=4a571033209b' target=_blank style='color:#2F92EE;'>#黑素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103320, encryptionId=4a571033209b, topicName=黑素瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d4d7523220, createdName=yuhaisheng_ibp_32061713, createdTime=Wed Nov 23 01:38:00 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157259, encodeId=4f3315e2596e, content=这也可以！, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Mon Nov 21 11:04:48 CST 2016, time=2016-11-21, status=1, ipAttribution=)]
    2016-11-21 䖝二

    这也可以！

    0

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