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J Pediatr Hematol Oncol:临床分期I期的睾丸间质瘤在青少年病人中的危险因素

2015-10-20 zhaoxin 译 MedSci原创

背景:睾丸间质瘤很罕见。在患有睾丸间质瘤的成年男性中,各种病理性危险因素显示:那些患有临床局限性疾病的患者,会增加得未知的转移性疾病的风险(OMD)。我们系统的回顾了现有文献,分析出它们在青春期前(0-12岁)和青春期后(13-21岁)得未知的转移性疾病的病人中,对这些危险因素的影响。方法:进行文献检索使用的检索词为:“睾丸间质瘤”、睾丸间质细胞肿瘤、睾丸滋养肿瘤、睾丸间质性肿瘤、睾丸颗粒性肿瘤、

背景:睾丸间质瘤很罕见。在患有睾丸间质瘤的成年男性中,各种病理性危险因素显示:那些患有临床局限性疾病的患者,会增加得未知的转移性疾病的风险(OMD)。我们系统的回顾了现有文献,分析出它们在青春期前(0-12岁)和青春期后(13-21岁)得未知的转移性疾病的病人中,对这些危险因素的影响。

方法进行文献检索使用的检索词为:“睾丸间质瘤”、“睾丸间质细胞肿瘤”、“睾丸滋养肿瘤”、“睾丸间质性肿瘤”、“睾丸颗粒性肿瘤”、“睾丸性脊髓肿瘤”。被研究者是年龄为0-21岁的患有临床I期的肿瘤间质瘤患者。

结果:来自30篇论文中的总共100名患者,诊断的平均年龄为5.7年(范围1.2个月到21 年)。其中七十九名患者12年及以下(平均7.2个月)和21名患者为13到21年(平均16 年)。两组患者都在腹膜后淋巴结清扫术或随访监测(平均随访年龄为45.6 岁(范围为4 - 30年)后未发现发生转移。99%的12年的患者和低于95%的12年以上的患者有0到1个病理危险因素,相对应的1%的12年患者和5%的12年以上的患者有2个以上的病理危险因素(P = 0.38)。

结论:在I期睾丸间质瘤的青少年中,那些具有良好生活态度的青春期后的患者与青春期前的患者表现类似,有极少的病理性危险因素。鉴于在这个人群中复发率较低,低强度监测策略是至关重要的。对这些患者的前瞻性研究是必要的;和在国际卵巢和睾丸间质肿瘤等肿瘤登记系统进行注册,学习更多关于这种罕见的疾病的相关知识是很重要的。

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    2015-10-21 feather89
  2. [GetPortalCommentsPageByObjectIdResponse(id=1725905, encodeId=d5231e25905e0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Oct 21 17:55:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864714, encodeId=b0261864e1475, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 11 11:55:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637178, encodeId=2988163e178fc, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jun 10 21:55:00 CST 2016, time=2016-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317240, encodeId=db83131e2401e, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368309, encodeId=0765136830914, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425988, encodeId=e701142598877, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40072, encodeId=a679400e25b, content=翻译不是很地道,感觉没读懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eaa1657487, createdName=泌外新手, createdTime=Wed Oct 21 15:50:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
    2016-06-11 minlingfeng
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1725905, encodeId=d5231e25905e0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Oct 21 17:55:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864714, encodeId=b0261864e1475, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 11 11:55:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637178, encodeId=2988163e178fc, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jun 10 21:55:00 CST 2016, time=2016-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317240, encodeId=db83131e2401e, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368309, encodeId=0765136830914, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425988, encodeId=e701142598877, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40072, encodeId=a679400e25b, content=翻译不是很地道,感觉没读懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eaa1657487, createdName=泌外新手, createdTime=Wed Oct 21 15:50:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
    2015-10-22 fengyi812
  5. [GetPortalCommentsPageByObjectIdResponse(id=1725905, encodeId=d5231e25905e0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Oct 21 17:55:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864714, encodeId=b0261864e1475, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 11 11:55:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637178, encodeId=2988163e178fc, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jun 10 21:55:00 CST 2016, time=2016-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317240, encodeId=db83131e2401e, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368309, encodeId=0765136830914, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425988, encodeId=e701142598877, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40072, encodeId=a679400e25b, content=翻译不是很地道,感觉没读懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eaa1657487, createdName=泌外新手, createdTime=Wed Oct 21 15:50:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
    2015-10-22 zhangph
  6. [GetPortalCommentsPageByObjectIdResponse(id=1725905, encodeId=d5231e25905e0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Oct 21 17:55:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864714, encodeId=b0261864e1475, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 11 11:55:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637178, encodeId=2988163e178fc, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jun 10 21:55:00 CST 2016, time=2016-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317240, encodeId=db83131e2401e, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368309, encodeId=0765136830914, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425988, encodeId=e701142598877, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40072, encodeId=a679400e25b, content=翻译不是很地道,感觉没读懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eaa1657487, createdName=泌外新手, createdTime=Wed Oct 21 15:50:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1725905, encodeId=d5231e25905e0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Oct 21 17:55:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864714, encodeId=b0261864e1475, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 11 11:55:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637178, encodeId=2988163e178fc, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jun 10 21:55:00 CST 2016, time=2016-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317240, encodeId=db83131e2401e, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368309, encodeId=0765136830914, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425988, encodeId=e701142598877, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Thu Oct 22 14:55:00 CST 2015, time=2015-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40072, encodeId=a679400e25b, content=翻译不是很地道,感觉没读懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eaa1657487, createdName=泌外新手, createdTime=Wed Oct 21 15:50:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
    2015-10-21 泌外新手

    翻译不是很地道,感觉没读懂

    0

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