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Eur Heart J :疲劳:社会心理因素对于冠心病风险的预测性

2015-02-20 张旭栋 MedSci原创

对于冠心病的预防人群研究起始于1940年,而介入治疗也是从之后的1970年开始的。1961年,冠心病的风险因子首次在Framingham Study中发表,其中包括高血压,高血脂等等。之后又有新的风险因子被添加。1970年,心理社会因素也被添加入冠心病的风险因子中。开创性的心脏病研究,源于52个国家的15152例心梗病例分析中提到,传统风险因子对于90%的患者具有预测性,而心理社会因素也对32

对于冠心病的预防人群研究起始于1940年,而介入治疗也是从之后的1970年开始的。1961年,冠心病的风险因子首次在Framingham Study中发表,其中包括高血压,高血脂等等。之后又有新的风险因子被添加。1970年,心理社会因素也被添加入冠心病的风险因子中。开创性的心脏病研究,源于52个国家的15152例心梗病例分析中提到,传统风险因子对于90%的患者具有预测性,而心理社会因素也对32.5%患者具有预测性。而传统风险因子与心理社会因素之间的比较,目前还未曾研究发表过。冠心病中风险因子包括个人因素与社会因素。个人因素包括疲劳, 社交,以及主要生活事件。丹麦哥本哈根腓特烈斯贝医院,心脏研究中的Peter Schnohr等人比较了冠心病患者中传统风险因素与心理社会因素之间的重要性,以及心理社会因素对于提高风险预测的意义。成果发表在2月份的Journal of the American College of Cardiology期刊上。

目的:研究心理因素与传统风险因子对于冠心病患者的重要性。
 
方法和结果:
1991年至1994年,从哥本哈根心脏研究(前瞻性心血管群体研究)随机抽取8882例无心血管疾病的患者,对他们进行评估,直至2013年4月。前向法,人群归因分值,和梯度分析用于测定行列。使用C-统计和净重新分类指数探索疲惫的风险预后。

结局:随访注册了1731例非致死性和致死性冠心病事件患者。其中,对于男性,排名最高的冠心病危险因素是疲劳程度(高与低之间的风险比:2.36; 95%置信区间,1.70-3.26; P <0.001)和收缩压(服用或不服用降压药后血压≥160毫米汞柱与<120毫米汞柱相比,其风险比是2.07;95%可信区间:1.48-2.88; P <0.001)。在女性中,排名最高的冠心病危险因素是吸烟(≥15克烟草/天与从不吸烟者相比,其风险比是:1.74;95%可信区间:1.43-2.11; P <0.001),其次是疲劳程度(高与低风险比:2.07;95 %可信区间1.61-2.68; P <0.001)。总的来说,疲劳会显著提高风险预测。
 
结论:
疲惫是冠心病的一项重要的风险因素,研究强调风险预测分数中心理社会因素的重要性。
 
原始出处:

Giustino G, Baber U, Sartori S, Mehran R, Mastoris I, Kini AS, Sharma SK, Pocock SJ, Dangas GD. Duration of Dual Antiplatelet Therapy Following Drug-Eluting Stent Implantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of the American College of Cardiology. 2015.

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    2015-03-05 xiaoai5777

    好文章,攒

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1801488, encodeId=e1ef1801488df, content=<a href='/topic/show?id=2dfae3977a2' target=_blank style='color:#2F92EE;'>#社会心理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73977, encryptionId=2dfae3977a2, topicName=社会心理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Jun 19 07:51:00 CST 2015, time=2015-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770978, encodeId=6cc11e70978b1, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Mon Sep 21 01:51:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17644, encodeId=83401e64476, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:27:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17639, encodeId=7d9b1e639a3, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17640, encodeId=dad21e64008, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17641, encodeId=2e381e641f4, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17642, encodeId=f1e41e642cd, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17643, encodeId=13d61e643db, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17638, encodeId=dc351e63857, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260809, encodeId=5e26126080900, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Sun Feb 22 13:51:00 CST 2015, time=2015-02-22, status=1, ipAttribution=)]
    2015-03-05 xiaoai5777

    好文章,攒

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1801488, encodeId=e1ef1801488df, content=<a href='/topic/show?id=2dfae3977a2' target=_blank style='color:#2F92EE;'>#社会心理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73977, encryptionId=2dfae3977a2, topicName=社会心理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Jun 19 07:51:00 CST 2015, time=2015-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770978, encodeId=6cc11e70978b1, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Mon Sep 21 01:51:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17644, encodeId=83401e64476, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:27:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17639, encodeId=7d9b1e639a3, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17640, encodeId=dad21e64008, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17641, encodeId=2e381e641f4, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17642, encodeId=f1e41e642cd, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17643, encodeId=13d61e643db, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17638, encodeId=dc351e63857, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260809, encodeId=5e26126080900, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Sun Feb 22 13:51:00 CST 2015, time=2015-02-22, status=1, ipAttribution=)]
    2015-03-05 xiaoai5777

    好文章,攒

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1801488, encodeId=e1ef1801488df, content=<a href='/topic/show?id=2dfae3977a2' target=_blank style='color:#2F92EE;'>#社会心理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73977, encryptionId=2dfae3977a2, topicName=社会心理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Jun 19 07:51:00 CST 2015, time=2015-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770978, encodeId=6cc11e70978b1, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Mon Sep 21 01:51:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17644, encodeId=83401e64476, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:27:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17639, encodeId=7d9b1e639a3, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17640, encodeId=dad21e64008, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17641, encodeId=2e381e641f4, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17642, encodeId=f1e41e642cd, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17643, encodeId=13d61e643db, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17638, encodeId=dc351e63857, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260809, encodeId=5e26126080900, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Sun Feb 22 13:51:00 CST 2015, time=2015-02-22, status=1, ipAttribution=)]
    2015-03-05 xiaoai5777

    好文章,攒

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1801488, encodeId=e1ef1801488df, content=<a href='/topic/show?id=2dfae3977a2' target=_blank style='color:#2F92EE;'>#社会心理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73977, encryptionId=2dfae3977a2, topicName=社会心理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Jun 19 07:51:00 CST 2015, time=2015-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770978, encodeId=6cc11e70978b1, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Mon Sep 21 01:51:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17644, encodeId=83401e64476, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:27:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17639, encodeId=7d9b1e639a3, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17640, encodeId=dad21e64008, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17641, encodeId=2e381e641f4, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17642, encodeId=f1e41e642cd, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17643, encodeId=13d61e643db, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:26:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17638, encodeId=dc351e63857, content=好文章,攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260809, encodeId=5e26126080900, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Sun Feb 22 13:51:00 CST 2015, time=2015-02-22, status=1, ipAttribution=)]
    2015-03-05 xiaoai5777

    好文章,攒

    0

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    2015-03-05 xiaoai5777

    好文章,攒

    0

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    2015-03-05 xiaoai5777

    好文章,攒

    0

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    2015-02-22 tamgche

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