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JCO：ASCO与CAP更新乳腺癌HER2检测指南

2013-11-20 中国医学论坛报 中国医学论坛报

ASCOCAPHER2检测指南
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美国临床肿瘤学会(ASCO)和美国病理学医师学院(CAP)更新了乳腺癌HER2检测指南。新指南推荐应用免疫组织化学染色(IHC)或原位杂交(ISH)提高HER2检测准确率。HER2阳性标准为Her-2蛋白过表达(IHC，镜下视野>10%的相邻同质性肿瘤组织细胞区域)和基因扩增(ISH，组织内至少20个细胞可见HER2 拷贝或HER2:CEP17);检测结果若与其他组织学检测不符须重复检测;检

美国临床肿瘤学会(ASCO)和美国病理学医师学院(CAP)更新了乳腺癌HER2检测指南。新指南推荐应用免疫组织化学染色(IHC)或原位杂交(ISH)提高HER2检测准确率。

HER2阳性标准为Her-2蛋白过表达(IHC，镜下视野>10%的相邻同质性肿瘤组织细胞区域)和基因扩增(ISH，组织内至少20个细胞可见HER2 拷贝或HER2:CEP17);检测结果若与其他组织学检测不符须重复检测;检测实验室的检测结果应与经验证的HER2检测结果有高度一致性;检测要在CAP等机构认证的实验室进行。该研究在线发表于10月7日 J Clin Oncol。

原文出处：

Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH, Allred DC, Bartlett JM, Bilous M, Fitzgibbons P, Hanna W, Jenkins RB, Mangu PB, Paik S, Perez EA, Press MF, Spears PA, Vance GH, Viale G, Hayes DF.Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update.J Clin Oncol. 2013 Nov 1;31(31):3997-4013. doi: 10.1200/JCO.2013.50.9984. Epub 2013 Oct 7.【原文下载】

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    2014-08-24 仁医06

    #HER2检测#

    0

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    2013-12-15 lidong40

    #JCO#

    0

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    2013-12-08 一叶知秋

    #ASC#

    0

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    2014-08-17 smlt2008

    #CAP#

    0

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