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BMJ Open:男性易发生不稳定型心绞痛

2015-10-20 Mechront 译 MedSci原创

不稳定型心绞痛,是介于劳累性稳定型心绞痛与急性心肌梗死和猝死之间的临床表现。主要包括初发心绞痛、恶化劳力性心绞痛、静息心绞痛伴心电图缺血改变和心肌梗死后早期心绞痛。其特征是心绞痛症状进行性增加,新发作的休息或夜间性心绞痛或出现心绞痛持续时间延长。研究者在芬兰进行了一项基于人群的回顾性研究,探究因不稳定型心绞痛(UAP)的住院率的性别差异和年龄差异。该研究纳入了2000年5月-2009年10月间、≥

不稳定型心绞痛,是介于劳累性稳定型心绞痛与急性心肌梗死和猝死之间的临床表现。主要包括初发心绞痛、恶化劳力性心绞痛、静息心绞痛伴心电图缺血改变和心肌梗死后早期心绞痛。其特征是心绞痛症状进行性增加,新发作的休息或夜间性心绞痛或出现心绞痛持续时间延长。

研究者在芬兰进行了一项基于人群的回顾性研究,探究因不稳定型心绞痛(UAP)的住院率的性别差异和年龄差异。该研究纳入了2000年5月-2009年10月间、≥30岁、因初次诊断UAP而入院的27282名患者。其中 61.9% 为男性, 38.1% 为女性。

校正年龄后,“男性”会增加UAP风险(RR 1.85;CI 1.61 to 2.14;p<0.0001)。整个研究期间,研究者观察到UAP的整体发病率为92.8/100 000人年(CI 91.8 - 93.9)。UAP发病率随年龄增长,30-34岁人群发病率为1.3/100 000,75-84岁人群的发病率为268.0/100 000。

在普通人群中,因UAP住院的事件中,男性风险是女性的2.4倍(ncidence rate ratio 2.39; CI 2.24 - 2.56; p<0.0001)。在每个年龄组都可以发现UAP发病的性别差异。

因UAP导致的急性冠脉综合征而住院的占22.4%,导致心血管疾病而住院的有4.7%。对于男性病人,UAP更容易导致心血管疾病(RR=1.25; CI 1.21 - 1.30, p<0.0001),但是在急性冠脉综合征这一块,性别间的差异不大,无统计学意义。

随着每个研究年的增长,一般人群中UAP住院率按约8%的速度下降,不管男性女性,还是少年老年,该下降是显著的。

研究结果表明,普通人群里男性因不稳定型心绞痛(UAP)住院的风险是女性的2.4倍。对于芬兰人群,UAP住院率呈下降趋势。

原始出处:

Kytö V, Sipilä J, Rautava P,et al.Gender-specific and age-specific differences in unstable angina pectoris admissions: a population-based registry study in Finland.BMJ Open. 2015 Oct 15;5(10):e009025.

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    2016-07-26 gaoxiaoe
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    2016-07-30 feather89
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