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Heart:心房颤动对心尖肥厚型心肌病病程的影响!

2017-04-22 xing.T MedSci原创

由此可见,在ApHCM患者中,房颤是常见的,并且与相当大卒中和死亡风险有关,这表明应该对ApHCM患者的AF进行精心管理。

心尖肥厚型心肌病(ApHCM)被认为是肥厚型心肌病的一个“良性”的形式,然而长期预后数据较为有限。然而,ApHCM患者心房颤动(AF)的临床影响在很大程度上是未知的。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员假设房颤在ApHCM患者中很常见,并且具有预后意义。

研究人员评估了连续就诊的306例ApHCM患者(68%为男性,62±11岁)AF的发生率和结局。

研究人员发生77例ApHCM患者发生了房颤(患病率为25.2%;年发病率为4.6%每年),并且可以被年龄较大和巨大的左心房(>45mm)进行独立预测。在70例有抗凝治疗指征的房颤患者中,53例(76%)患者接受了华法林治疗。在随访5.5±2年期间,AF患者出现全因死亡、心血管死亡和卒中的发生率较高(分别为11.7% vs. 1.3%,6.5% vs. 0.9%和19.5% vs. 2.6%,均P<0.05),相比于无AF患者,当调整了年龄和性别,那些AF患者全因死亡(风险比为6.58;95%可信区间为1.65-26.16,P=0.007)和卒中(风险比为5.13;95%可信区间为1.85-14.18,P=0.002)的风险仍然增加。15例同时患有AF和卒中的患者在卒中发生前就有8例(53%)患者检测AF。此外,8例患者中有6例患者在卒中发生时进行了抗凝治疗。其中,9例房颤患者中有3例(33%)患者死于卒中。

由此可见,在ApHCM患者中,房颤是常见的,并且与相当大卒中和死亡风险有关,这表明应该对ApHCM患者的AF进行精心管理

原始出处:

Sang-Eun Lee,et al. Impact of atrial fibrillation on the clinical course of apical hypertrophic cardiomyopathy. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2016-310720

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    2017-09-27 okhuali
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    2017-04-24 爆笑小医
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    2017-04-24 slcumt
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    2017-04-24 sodoo
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    2017-04-22 三生有幸9135

    学习一下谢谢分享

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