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Nat Rev Cardiol:戒烟降低非糖尿病患者心血管疾病风险

2013-04-11 Nat Rev Cardiol dxy

吸烟者总是借口戒烟会引起体重增加,而体重增加对心血管的坏处和继续吸烟一样多,不过,这个借口将不再成立。2013年3月13日发表于JAMA的前瞻性社区队列研究提示,尽管吸烟者在戒烟后短期内体重会有所增加,但他们发生心血管事件的风险只有继续吸烟者的一半,与长期戒烟者风险相近。研究者表示“如果能量化戒烟引起的增重与实际心血管疾病风险的关联,医生可以更好地劝说患者戒烟。”研究分析了弗明汉后代研究中3,25

吸烟者总是借口戒烟会引起体重增加,而体重增加对心血管的坏处和继续吸烟一样多,不过,这个借口将不再成立。2013年3月13日发表于JAMA的前瞻性社区队列研究提示,尽管吸烟者在戒烟后短期内体重会有所增加,但他们发生心血管事件的风险只有继续吸烟者的一半,与长期戒烟者风险相近。研究者表示“如果能量化戒烟引起的增重与实际心血管疾病风险的关联,医生可以更好地劝说患者戒烟。”
研究分析了弗明汉后代研究中3,251名受试者的数据,研究期间(1984-2011),吸烟率从31%降至13%。非糖尿病患者中,与长期戒烟者(戒烟时间>4年)、吸烟者和非吸烟者相比,近期戒烟者(戒烟时间≤4年)在四年内体重显著增加(P <0.001,长期戒烟者增重0.9 kg,吸烟者增重0.9 kg,非吸烟者增重1.4 kg,近期戒烟者增重2.7 kg)。糖尿病患者中结果与之类似。
经过6年的随访发现,非糖尿病患者中,尽管戒烟会引起体重增加,近期戒烟者和长期戒烟者心血管疾病事件的风险(HR 0.47, 95% CI 0.23–0.94; HR0.46, 95% CI 0.34–0.63)仅为吸烟者的一半。研究定义的心血管疾病事件包括冠心病死亡、心肌梗死、冠状动脉功能不全、心绞痛、缺血性中风、出血性中风、间歇性跛行和充血性心力衰竭。糖尿病患者中的研究结果有相似的趋势,但未构成统计学意义。研究人员总结认为“戒烟4年引起的增重不会抵消戒烟降低心血管疾病风险的益处。”
心血管相关的拓展阅读:


原文阅读:Risk factors: One less excuse for not quitting smoking
Cigarette smokers no longer have the excuse that quitting smoking would be almost as bad for their cardiovascular health as continuing to smoke, because of the weight gain often associated with smoking cessation. Results of a prospective, community-based cohort study published in JAMA indicate that, although smokers do put on weight shortly after quitting smoking, their risk of a cardiovascular disease event is approximately half that of individuals still smoking, and similar to people who were considered to be long-term quitters....

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    2013-05-09 liye789132251
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