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JAHA:心血管疾病患者体力活动与下呼吸道感染结局之间的相关性

2022-02-10 MedSci原创 MedSci原创

在心血管疾病患者中,与完全久坐相比,即使进行低水平的体力活动也能降低因下呼吸道感染导致的死亡和住院风险,并且研究人员观察到随着体力活动的增加,风险会逐渐降低。

证据表明,缺乏体力活动会增加各种疾病和全因死亡率的风险。根据这些数据,最近的指南建议进行体力活动以获得更好的健康结局。然而,体力活动对感染免疫功能的影响尚未得到充分探究。下呼吸道感染是发病率和死亡率的主要原因,约占2017年全球所有死亡人数的5%,其结果在老年人和免疫功能低下的人群中尤为严重。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员的目标是探究心血管疾病患者体力活动与下呼吸道感染结局之间的剂量反应关系。

研究人员使用韩国国民健康保险数据,确定了在2009年1月1日至2012年12月31日期间参加健康筛查的18至99岁(平均年龄为62.6±11.3岁;女性为49.6%)的心血管疾病患者(n=1048502),并随访至2018年的死亡和直至2019年的住院治疗情况。研究人员使用自我报告的问卷评估体力活动量并将其分为5组:0(完全久坐)、<500、500至999、1000至1499和≥1500代谢当量的任务分钟/周。

在控制各种混杂因素后,对于体力活动量为0(完全久坐)、<500、500至999、1000至1499和≥1500代谢当量的受试者发生下呼吸道感染的调整后风险比(95%CI)分别为1.00(参考)、0.74(0.70-0.78)、0.66(0.62-0.70)、0.52(0.47-0.57)和0.54(0.49-0.60),下呼吸道感染住院的分险比分别为1.00(参考)、0.84(0.83-0.85)、0.77(0.76-0.79)、0.72(0.70-0.73)和0.71(0.69-0.73)。假设0到2000代谢当量任务min/wk之间存在线性关联,每增加500代谢当量的的体力活动与下呼吸道感染死亡率和住院率分别降低22%和13%相关。老年人群中的这一负性关联强于年轻人群(交互作用P<0.01)。

由此可见,在心血管疾病患者中,与完全久坐相比,即使进行低水平的体力活动也能降低因下呼吸道感染导致的死亡和住院风险,并且研究人员观察到随着体力活动的增加,风险会逐渐降低。

原始出处:

Mi‐Hyang Jung.etal.Association of Physical Activity and Lower Respiratory Tract Infection Outcomes in Patients With Cardiovascular Disease.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.023775

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    2022-02-11 zhaohui6731
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    2022-02-11 zhmscau
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