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Diabetologia:产妇妊娠期糖尿病或与后代认知下降有关

2013-12-23 佚名 丁香园

研究要点: 1.该研究探讨产妇妊娠期糖尿病与后代认知能力的关系; 2.发现产妇妊娠期糖尿病或与后代认知下降有关; 3.这种相关性可以通过共同的家族特征来解释。 为了探讨产妇妊娠期糖尿病与后代认知能力的关系,并评估这种相关性是否由宫内机制或共同的家族特征引起,来自英国布里斯托大学的Abigail Fraser教授及其团队进行了一项研究,该研究发现产妇妊

研究要点:

1.该研究探讨产妇妊娠期糖尿病与后代认知能力的关系;

2.发现产妇妊娠期糖尿病或与后代认知下降有关;

3.这种相关性可以通过共同的家族特征来解释。

为了探讨产妇妊娠期糖尿病与后代认知能力的关系,并评估这种相关性是否由宫内机制或共同的家族特征引起,来自英国布里斯托大学的Abigail Fraser教授及其团队进行了一项研究,该研究发现产妇妊娠期糖尿病或与后代认知下降有关,这种相关性可以通过共同的家族特征来解释。该研究结果在线发表在2013年09月25日的Diabetologia杂志上。 【原文下载】

该研究小组联合瑞典国家登记处对瑞典出生的单胎男婴进行一相前瞻性队列研究,探讨产妇妊娠期糖尿病与后代16岁时教育成就、完成瑞典义务教育的年龄和18岁强制征兵检查时的智商的关系。

该研究结果表明,即使在矫正产妇生产年龄、产次、受教育程度、孕前BMI、后代出生年份、胎龄和出生体重后,产妇妊娠期糖尿病也与后代(无血缘关系)认知能力降低有关。例如,妊娠期有糖尿病的母亲生下男孩智商比没有糖尿病母亲生下的男孩平均低1.36分。相比之下,有血缘关系的男孩中未发现这种相关性。

该研究发现,产妇妊娠期糖尿病与后代认知结局的关系可以通过共同的家族特征,而不是宫内机制来解释。

研究背景:

很多研究比较妊娠期有糖尿病母亲后代与妊娠期没有糖尿病母亲后代的认知指标,发现西方人群中,糖尿病母亲的后代某些认知指标评分下降,但总的智商没有下降。使用瑞典人口登记数据进行的最大流行病学研究发现产妇妊娠糖尿病与后代16岁时教育成就下降有关。

原文出处:

Fraser A, Almqvist C, Larsson H, Långström N, Lawlor DA.Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families.Diabetologia. 2014 Jan;57(1):102-9. doi: 10.1007/s00125-013-3065-z.Epub 2013 Sep 25. 【原文下载】

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