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CLIN CANCER RES：结直肠癌肿瘤异质性预测转移可能

2017-12-03 MedSci MedSci原创

结直肠癌肿瘤异质性转移
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肿瘤具有持续生长的能力，继发突变有助于这一过程，最终导致高度的肿瘤异质性。CLIN CANCER RES近期发表了一篇文章，比较原发和继发结直肠肿瘤标本，研究肿瘤异质性是否可以预测肿瘤转移。

肿瘤具有持续生长的能力，继发突变有助于这一过程，最终导致高度的肿瘤异质性。CLIN CANCER RES近期发表了一篇文章，比较原发和继发结直肠肿瘤标本，研究肿瘤异质性是否可以预测肿瘤转移。

作者对46对匹配的原发-肝转移肿瘤和42个无转移原发肿瘤进行全染色体测序以了解体细胞突变情况。通过单核苷酸和拷贝数改变评估肿瘤克隆性。评估患者临床特征和肝转移克隆异质性之间的关系。研究结果表明，不同结直肠肿瘤标本之间肿瘤异质性差异很大，但高肿瘤异质性与不良无病生存有关。异质性高的结直肠癌与肝转移率高有关。在异质性高的结直肠癌中，APC、TP53和KRAS突变频率高。这些突变等位基因变异频率高，而其他基因体细胞突变如PIK3CA和NOTCH1低。在转移肿瘤中可以观察到原发结直肠癌亚克隆的分布。

文章最后认为，原发结直肠癌异质性可以预测肝转移可能及患者临床结局。

原始出处：
Je-Gun Joung,Bo Young Oh,et al.Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer.CLIN CANCER RES.December 2017 doi:10.1158/1078-0432.CCR-17-0306

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    2018-04-05 shalley66

    #肠癌肿瘤#

    0

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    2017-12-04 crystal0564

    #结直肠#

    0

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    2017-12-03 蔬菜

    肿瘤异质性可能会影响肿瘤很多的生物学行为

    0

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    2017-12-03 lovetcm

    肿瘤异质性可能会影响到肿瘤很多的生物学行为

    0

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