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JAHA:左心室肥厚与接受经皮冠状动脉介入治疗的STEMI患者的梗死面积增大有关!

2017-01-10 xing.T MedSci原创

在经皮冠状动脉介入治疗的STEMI患者中,LVH与较大的心肌梗死面积、较少的心肌挽救、较高的微血管阻塞、较低的LVEF、较高的死亡率和心力衰竭发生风险独立相关。

约有三分之一的ST段抬高型心肌梗死患者(STEMI)发生左心室肥厚(LVH),这与患者不良预后相关,然而,LVH与STEMI患者预后之间的因果关系仍为未知。近日,心血管病领域权威杂志JAHA上发表了一研究文章,研究者在接受经皮冠状动脉介入治疗的STEMI患者中评估了LVH与心肌梗死面积、区域风险、挽救的心肌细胞、血管阻塞、LV功能(通过心脏磁共振[CMR]来确定)、全因死亡率和因心衰再住院之间的相关性。

该研究属于DANAMI-3试验的子研究,研究人员共纳入了764例接受CMR检查的患者。LVH是通过CMR来确定,目前认为如果LV质量超过77g/m2(男性)和67g/m2(女性)就存在LVH。

研究者发现178例(24%)患者存在LVH,并且LVH与较大的最终梗死面积(15%[四分位间距{IQR}为10-21] vs. 9% [3-17];P<0.001)和较小的最终心肌挽救指数(0.6 [0.5-0.7] vs. [0.5-0.9];P<0.001)相关。LVH组患者微血管阻塞的发生率(66% vs. 45%;P<0.001)较高,而最终的左室射血分数(LVEF;53% [47-60]vs. 61% [55-65];P<0.001)。在Cox回归分析中,LVH与较高的全因死亡率和因心衰再住院风险相关(危险比为2.59 [1.38-4.90],95%可信区间为1.38-4.90,P=0.003)。在多变量模型中,这些结果仍然具有统计学意义。

由此可见,在经皮冠状动脉介入治疗的STEMI患者中,LVH与较大的心肌梗死面积、较少的心肌挽救、较高的微血管阻塞、较低的LVEF、较高的死亡率和心力衰竭发生风险独立相关。

原始出处:

Lars Nepper‐Christensen, et al. Left Ventricular Hypertrophy Is Associated With Increased Infarct Size and Decreased Myocardial Salvage in Patients With ST‐Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary
Intervention
. JAHA.2017. 

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2017-01-12 zhaohui6731
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