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CGH:结肠镜检查结果影响了非结直肠癌死亡率

2022-04-08 xuyihan MedSci原创

本项研究证实在 CRC 筛查人群中,那些在 10 年内死于非 CRC 原因的人更有可能在基线结肠镜检查中发现生活习惯的高风险危害。

临床上我们发现大多数接受常规结直肠癌(CRC)筛查和监测的人将死于CRC以外的原因。因此,CRC筛查是一个机会能够帮助预防与CRC无关的不良后果。目前关于各种危险因素对健康筛查人群中非结直肠癌 (CRC) 死亡率的影响存在争议,比如许多饮食和生活方式因素与过早死亡有密切的联系,在某些情况下还可能在CRC筛查后恶化患者的身体健康。

因此,本项研究旨在探究已知 CRC 危险因素(包括基线结肠镜检查结果)对筛查人群中非 CRC 死亡率的影响。

本项研究纳入的人群由3121名 50-75 岁的退伍军人组成,他们均在在 1994-97 年间接受了结肠镜检查,然后被跟踪至少 10 年或直至患者出现死亡。通过多变量 Cox 比例风险估计非 CRC 死亡率的风险因素的风险比 (HR)。

研究结果显示:当前吸烟(HR 2.12,95% CI 1.78-2.52)和身体运动较少(HR 0.89,95% CI 0.84-0.93)是与非 CRC 死亡率最相关的可改变因素。此外,与基线结肠镜检查无肿瘤相比,≥3 个小腺瘤(HR 1.43, 95% CI 1.06-1.94)、晚期腺瘤(HR 1.32, 95% CI 0.99-1.75)和CRC (HR 2.95, 95% CI 0.98-8.85)的诊断均与死亡率相关,但是具有 1-2 个小腺瘤的患者非 CRC 死亡率的风险没有增加(HR 1.15,95% CI 0.94-1.4)。

图:结肠镜检查结果与死亡率的相关性

 

本项研究证实在 CRC 筛查人群中,那些在 10 年内死于非 CRC 原因的人更有可能在基线结肠镜检查中发现生活习惯的高风险危害。这些结果表明,晚期结肠镜检查结果可能是健康状况不佳的风险标志。

 

原始出处:

Sullivan, Brian A. et al. Screening Colonoscopy Findings are Associated with nonColorectal Cancer Mortality. Clinical and Translational Gastroenterology.2022.

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    2022-11-04 chendoc242
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    2022-04-08 ms4000001369647062

    1

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    2022-04-08 zhouqu_8
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